Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort

OBJECTIVES: To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes. METHODS: We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical...

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Autores principales: Guellec, Dewi, Milin, Morgane, Cornec, Divi, Tobon, Gabriel J, Marhadour, Thierry, Jousse-Joulin, Sandrine, Chiocchia, Gilles, Vittecocq, Olivier, Devauchelle-Pensec, Valérie, Saraux, Alain
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BMJ Publishing Group 2015
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613150/
https://www.ncbi.nlm.nih.gov/pubmed/26509068
http://dx.doi.org/10.1136/rmdopen-2015-000070
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author Guellec, Dewi
Milin, Morgane
Cornec, Divi
Tobon, Gabriel J
Marhadour, Thierry
Jousse-Joulin, Sandrine
Chiocchia, Gilles
Vittecocq, Olivier
Devauchelle-Pensec, Valérie
Saraux, Alain
author_facet Guellec, Dewi
Milin, Morgane
Cornec, Divi
Tobon, Gabriel J
Marhadour, Thierry
Jousse-Joulin, Sandrine
Chiocchia, Gilles
Vittecocq, Olivier
Devauchelle-Pensec, Valérie
Saraux, Alain
author_sort Guellec, Dewi
collection PubMed
description OBJECTIVES: To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes. METHODS: We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm(3), at baseline and after 3 years. Features of patients with and without baseline eosinophilia were compared. RESULTS: Baseline eosinophilia was evidenced in 26 of 804 (3.2%) patients; their mean eosinophil count was 637.7±107/mm(3). Baseline eosinophilia was ascribed to atopic syndrome in 6 of 26 (23.1%) patients. After 3 years, patients with eosinophilia had higher Health Assessment Questionnaire scores (0.9 vs 0.5, p=0.004), higher patient visual analogue scale activity score and morning stiffness intensity (p=0.05), and were more often taking disease-modifying antirheumatic drugs (p=0.02). Baseline eosinophilia was not associated with presence of extra-articular manifestations. CONCLUSIONS: Eosinophilia is rare in recent-onset arthritis suggestive of RA, and is usually directly related to the rheumatic disease. Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without.
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spelling pubmed-46131502015-10-27 Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort Guellec, Dewi Milin, Morgane Cornec, Divi Tobon, Gabriel J Marhadour, Thierry Jousse-Joulin, Sandrine Chiocchia, Gilles Vittecocq, Olivier Devauchelle-Pensec, Valérie Saraux, Alain RMD Open Early Arthritis OBJECTIVES: To determine the prevalence of eosinophilia in patients with recent-onset arthritis suggestive of rheumatoid arthritis (RA) and to describe their features and outcomes. METHODS: We performed an ancillary study of data from a French prospective multicentre cohort study monitoring clinical, laboratory and radiographic data in patients with inflammatory arthritis of 6 weeks to 6 months duration. We determined the proportion of patients with eosinophilia, defined as a count >500/mm(3), at baseline and after 3 years. Features of patients with and without baseline eosinophilia were compared. RESULTS: Baseline eosinophilia was evidenced in 26 of 804 (3.2%) patients; their mean eosinophil count was 637.7±107/mm(3). Baseline eosinophilia was ascribed to atopic syndrome in 6 of 26 (23.1%) patients. After 3 years, patients with eosinophilia had higher Health Assessment Questionnaire scores (0.9 vs 0.5, p=0.004), higher patient visual analogue scale activity score and morning stiffness intensity (p=0.05), and were more often taking disease-modifying antirheumatic drugs (p=0.02). Baseline eosinophilia was not associated with presence of extra-articular manifestations. CONCLUSIONS: Eosinophilia is rare in recent-onset arthritis suggestive of RA, and is usually directly related to the rheumatic disease. Our data suggest that patients with mild eosinophilia at diagnosis could respond worse to the treatment than those without. BMJ Publishing Group 2015-07-15 /pmc/articles/PMC4613150/ /pubmed/26509068 http://dx.doi.org/10.1136/rmdopen-2015-000070 Text en Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions This is an Open Access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/
spellingShingle Early Arthritis
Guellec, Dewi
Milin, Morgane
Cornec, Divi
Tobon, Gabriel J
Marhadour, Thierry
Jousse-Joulin, Sandrine
Chiocchia, Gilles
Vittecocq, Olivier
Devauchelle-Pensec, Valérie
Saraux, Alain
Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title_full Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title_fullStr Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title_full_unstemmed Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title_short Eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the ESPOIR cohort
title_sort eosinophilia predicts poor clinical outcomes in recent-onset arthritis: results from the espoir cohort
topic Early Arthritis
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613150/
https://www.ncbi.nlm.nih.gov/pubmed/26509068
http://dx.doi.org/10.1136/rmdopen-2015-000070
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