Cargando…

New Anti-Nodal Monoclonal Antibodies Targeting the Nodal Pre-Helix Loop Involved in Cripto-1 Binding

Nodal is a potent embryonic morphogen belonging to the TGF-β superfamily. Typically, it also binds to the ALK4/ActRIIB receptor complex in the presence of the co-receptor Cripto-1. Nodal expression is physiologically restricted to embryonic tissues and human embryonic stem cells, is absent in normal...

Descripción completa

Detalles Bibliográficos
Autores principales:	Focà, Annalia, Sanguigno, Luca, Focà, Giuseppina, Strizzi, Luigi, Iannitti, Roberta, Palumbo, Rosanna, Hendrix, Mary J. C., Leonardi, Antonio, Ruvo, Menotti, Sandomenico, Annamaria
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613256/ https://www.ncbi.nlm.nih.gov/pubmed/26370966 http://dx.doi.org/10.3390/ijms160921342

Ejemplares similares

Effects of a novel Nodal-targeting monoclonal antibody in melanoma
por: Strizzi, Luigi, et al.
Publicado: (2015)

Generation and Characterization of Monoclonal Antibodies against a Cyclic Variant of Hepatitis C Virus E2 Epitope 412-422
por: Sandomenico, Annamaria, et al.
Publicado: (2016)

Translational significance of Nodal, Cripto-1 and Notch4 in adult nevi
por: Strizzi, Luigi, et al.
Publicado: (2016)

Production in Bacteria and Characterization of Engineered Humanized Fab Fragment against the Nodal Protein
por: Sivaccumar, Jwala P., et al.
Publicado: (2023)

Members of the GADD45 Protein Family Show Distinct Propensities to form Toxic Amyloid-Like Aggregates in Physiological Conditions
por: Smaldone, Giovanni, et al.
Publicado: (2021)

New Insights into Cancer Targeted Therapy: Nodal and Cripto-1 as Attractive Candidates
por: Arboretto, Paola, et al.
Publicado: (2021)

APEH Inhibition Affects Osteosarcoma Cell Viability via Downregulation of the Proteasome
por: Palumbo, Rosanna, et al.
Publicado: (2016)

Probing the interaction interface of the GADD45β/MKK7 and MKK7/DTP3 complexes by chemical cross-linking mass spectrometry
por: Rega, Camilla, et al.
Publicado: (2018)

Development of a New Highly Selective Monoclonal Antibody against Preferentially Expressed Antigen in Melanoma (PRAME) and Identification of the Target Epitope by Bio-Layer Interferometry
por: Sivaccumar, Jwala Priyadarsini, et al.
Publicado: (2021)

Cripto promotes A–P axis specification independently of its stimulatory effect on Nodal autoinduction
por: D'Andrea, Daniela, et al.
Publicado: (2008)

Nodal-dependent Cripto signaling promotes cardiomyogenesis and redirects the neural fate of embryonic stem cells
por: Parisi, Silvia, et al.
Publicado: (2003)

Pegylated Trastuzumab Fragments Acquire an Increased in Vivo Stability but Show a Largely Reduced Affinity for the Target Antigen
por: Selis, Fabio, et al.
Publicado: (2016)

A GPI processing phospholipase A2, PGAP6, modulates Nodal signaling in embryos by shedding CRIPTO
por: Lee, Gun-Hee, et al.
Publicado: (2016)

Evolution of Escherichia coli Expression System in Producing Antibody Recombinant Fragments
por: Sandomenico, Annamaria, et al.
Publicado: (2020)

Expression and functional role of CRIPTO-1 in cutaneous melanoma
por: De Luca, A, et al.
Publicado: (2011)

Nodal
por: PerrioIIat, F, et al.
Publicado: (1991)

Nodal
por: Perriollat, F
Publicado: (1992)

Nodal staging score and adequacy of nodal staging
por: Chen, Hui-Min, et al.
Publicado: (2019)

Potential for the embryonic morphogen Nodal as a prognostic and predictive biomarker in breast cancer
por: Strizzi, Luigi, et al.
Publicado: (2012)

Recent Applications of Retro-Inverso Peptides
por: Doti, Nunzianna, et al.
Publicado: (2021)

Dirac nodal surfaces and nodal lines in ZrSiS
por: Fu, B.-B., et al.
Publicado: (2019)

Melanocytes Affect Nodal Expression and Signaling in Melanoma Cells: A Lesson from Pediatric Large Congenital Melanocytic Nevi
por: Margaryan, Naira V., et al.
Publicado: (2016)

Human Cerberus Prevents Nodal-Receptor Binding, Inhibits Nodal Signaling, and Suppresses Nodal-Mediated Phenotypes
por: Aykul, Senem, et al.
Publicado: (2015)

Nodal staging
por: Ganeshalingam, Skandadas, et al.
Publicado: (2009)

NODAL functions
por: Guillaume, C
Publicado: (1982)

NODAL Primer
por: Lundberg, K H
Publicado: (1985)

NODAL Debugger
por: Lacroix, A
Publicado: (1986)

Inverse nodal problems: finding the potential from nodal lines
por: Hald, Ole H, et al.
Publicado: (1996)

The interface between compiled or Nodal programs and Nodal-compatible functions
por: Cailliau, R, et al.
Publicado: (1979)

Hexagonal Zr(3)X (X = Al, Ga, In) Metals: High Dynamic Stability, Nodal Loop, and Perfect Nodal Surface States
por: Xu, Heju, et al.
Publicado: (2020)

Three‐dimensional mapping of junctional beats during atrioventricular nodal reentrant tachycardia cryoablation
por: De Ruvo, Ermenegildo, et al.
Publicado: (2022)

Advanced NODAL course: Session 1 mini-computer systems and NODAL
por: Harrison, C G
Publicado: (1977)

Keeping a lid on nodal: transcriptional and translational repression of nodal signalling
por: Sampath, Karuna, et al.
Publicado: (2016)

Pure Zirconium: Type II Nodal Line and Nodal Surface States
por: Zhang, Li, et al.
Publicado: (2020)

Dirac Magnon Nodal Loops in Quasi-2D Quantum Magnets
por: Owerre, S. A.
Publicado: (2017)

Normal Skin Cells Increase Aggressiveness of Cutaneous Melanoma by Promoting Epithelial-to-Mesenchymal Transition via Nodal and Wnt Activity
por: Untiveros, Gustavo, et al.
Publicado: (2021)

The writing of nodal programs
por: Cailliau, R
Publicado: (1977)

The NODAL system for the SPS
por: Crowley-Milling, Michael C, et al.
Publicado: (1978)

Nodal Liquids and Duality
por: Mavromatos, Nikolaos E, et al.
Publicado: (2000)

The NODAL - FORTRAN Interface
por: Mellor, S J
Publicado: (1976)

Cannot write session to /tmp/vufind_sessions/sess_s8i16a803e2c7adh2kn3dn6in1