Cargando…

A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats

Broad-spectrum drugs appear to be more promising for the treatment of acute ischemic stroke. In our previous work, a new ligustrazine derivative (3,5,6-trimethylpyrazin-2-yl) methyl 3-methoxy-4-[(3,5,6-trimethylpyrazin-2-yl)methoxy]benzoate (T-VA) showed neuroprotective effect on injured PC12 cells...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Guoling, Tian, Yufei, Zhang, Yuzhong, Hong, Ying, Hao, Yingzhi, Chen, Chunxiao, Wang, Penglong, Lei, Haimin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613278/ https://www.ncbi.nlm.nih.gov/pubmed/26370988 http://dx.doi.org/10.3390/ijms160921759

Ejemplares similares

Correction: Li, G., et al. A Novel Ligustrazine Derivative T-VA Prevents Neurotoxicity in Differentiated PC12 Cells and Protects the Brain against Ischemia Injury in MCAO Rats. Int. J. Mol. Sci. 2015, 16, 21759–21774
por: Li, Guoliang, et al.
Publicado: (2016)

Synthesis and Protective Effect of New Ligustrazine-Benzoic Acid Derivatives against CoCl(2)-Induced Neurotoxicity in Differentiated PC12 Cells
por: Wang, Penglong, et al.
Publicado: (2013)

Synthesis and protective effect of new ligustrazine-vanillic acid derivatives against CoCl(2)-induced neurotoxicity in differentiated PC12 cells
por: Xu, Bing, et al.
Publicado: (2017)

Amino Acid Derivatives of Ligustrazine-Oleanolic Acid as New Cytotoxic Agents
por: Chu, Fuhao, et al.
Publicado: (2014)

Ligustrazinyl amides: a novel class of ligustrazine-phenolic acid derivatives with neuroprotective effects
por: Li, Guoliang, et al.
Publicado: (2015)

A Series of New Ligustrazine-Triterpenes Derivatives as Anti-Tumor Agents: Design, Synthesis, and Biological Evaluation
por: Xu, Bing, et al.
Publicado: (2015)

Synthesis and Biological Evaluation of New Ligustrazine Derivatives as Anti-Tumor Agents
por: Wang, Penglong, et al.
Publicado: (2012)

Ligustrazine-Oleanolic Acid Glycine Derivative, G-TOA, Selectively Inhibited the Proliferation and Induced Apoptosis of Activated HSC-T6 Cells
por: Bi, Siling, et al.
Publicado: (2016)

A New Ligustrazine Derivative-Selective Cytotoxicity by Suppression of NF-κB/p65 and COX-2 Expression on Human Hepatoma Cells. Part 3
por: Zhang, Chenze, et al.
Publicado: (2015)

Design, Synthesis and Biological Evaluation of Ligustrazine-Flavonoid Derivatives as Potential Anti-Tumor Agents
por: Wang, Hui, et al.
Publicado: (2018)

Ligustrazine monomer against cerebral ischemia/reperfusion injury
por: Gao, Hai-jun, et al.
Publicado: (2015)

Paeonolum protects against MPP(+)-induced neurotoxicity in zebrafish and PC12 cells
por: Lu, Xi-Lin, et al.
Publicado: (2015)

Protective Effect of Resveratrol Against Corticosterone-induced Neurotoxicity in PC12 Cells
por: Zhang, Ye, et al.
Publicado: (2019)

Astaxanthin Protects PC12 Cells against Homocysteine- and Glutamate-Induced Neurotoxicity
por: Chang, Chi-Huang, et al.
Publicado: (2020)

Ligustrazine Nanoparticle Hitchhiking on Neutrophils for Enhanced Therapy of Cerebral Ischemia‐Reperfusion Injury
por: Mu, Qingchun, et al.
Publicado: (2023)

Novel Neuroprotective Lead Compound Ligustrazine Derivative Mass Spectrometry Fragmentation Rule and Metabolites in Rats by LC/LTQ-Orbitrap MS
por: Zhang, Xinyu, et al.
Publicado: (2018)

Curcumin Protects β-Lactoglobulin Fibril Formation and Fibril-Induced Neurotoxicity in PC12Cells
por: Mazaheri, Mansooreh, et al.
Publicado: (2015)

Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
por: Wang, Qiuhong, et al.
Publicado: (2012)

Sedum takesimense Protects PC12 Cells against Corticosterone-Induced Neurotoxicity by Inhibiting Neural Apoptosis
por: Yun, Hea-Yeon, et al.
Publicado: (2020)

Repeated Oral Administration of Human Serum Albumin Protects from the Cerebral Ischemia in Rat Brain Following MCAO
por: Park, Hyejin, et al.
Publicado: (2017)

Ultraviolet Photolysis of Chlorpyrifos: Developmental Neurotoxicity Modeled in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2009)

Chlorogenic acid protects PC12 cells against corticosterone-induced neurotoxicity related to inhibition of autophagy and apoptosis
por: Shi, Xiaowen, et al.
Publicado: (2019)

Protective effects of macamides from Lepidium meyenii Walp. against corticosterone-induced neurotoxicity in PC12 cells
por: Yu, Zejun, et al.
Publicado: (2019)

Effect of Salvia miltiorrhiza and ligustrazine injection on myocardial ischemia/reperfusion and hypoxia/reoxygenation injury
por: Huang, Wendong, et al.
Publicado: (2016)

The combination of Astragalus membranaceus extract and ligustrazine to improve the inflammation in rats with thrombolytic cerebral ischemia
por: Pan, Ruihuan, et al.
Publicado: (2019)

Global gene expression profile of cerebral ischemia-reperfusion injury in rat MCAO model
por: Wang, Chunmei, et al.
Publicado: (2017)

Experimental study on the neurotoxic effect of β-amyloid on the cytoskeleton of PC12 cells
por: Wang, Lai, et al.
Publicado: (2018)

Pharmacokinetic study on the effect of ligustrazine–tangeretin co‐administration on the pharmacokinetics of ligustrazine and its potential mechanism in rats
por: Liu, Dandan, et al.
Publicado: (2023)

The Aqueous Extract of Rhizome of Gastrodia elata Protected Drosophila and PC12 Cells against Beta-Amyloid-Induced Neurotoxicity
por: Ng, Chun-Fai, et al.
Publicado: (2013)

Mitogen-activated protein kinase phosphatase 1 protects PC12 cells from amyloid beta-induced neurotoxicity
por: Gu, Yue, et al.
Publicado: (2018)

(−)-Epigallocatechin-3-gallate protects PC12 cells against corticosterone-induced neurotoxicity via the hedgehog signaling pathway
por: Feng, Sha, et al.
Publicado: (2018)

Bryonolic Acid, a Triterpenoid, Protect Against N-methyl-d-Aspartate-Induced Neurotoxicity in PC12 Cells
por: Que, Jinhua, et al.
Publicado: (2016)

Amauroderma rugosum Protects PC12 Cells against 6-OHDA-Induced Neurotoxicity through Antioxidant and Antiapoptotic Effects
por: Li, Jingjing, et al.
Publicado: (2021)

Protective Effect of Cinnamaldehyde on METH-induced Neurotoxicity in PC12 Cells via Inhibition of Apoptotic Response and Oxidative Stress
por: Rashidi, Roghayeh, et al.
Publicado: (2021)

Fucoxanthin Prevents Long-Term Administration l-DOPA-Induced Neurotoxicity through the ERK/JNK-c-Jun System in 6-OHDA-Lesioned Mice and PC12 Cells
por: Liu, Jingwangwei, et al.
Publicado: (2022)

Ameliorating the Developmental Neurotoxicity of Chlorpyrifos: A Mechanisms-Based Approach in PC12 Cells
por: Slotkin, Theodore A., et al.
Publicado: (2007)

Protective effect of ligustrazine on oxidative stress and apoptosis following testicular torsion in rats
por: Chen, Songmao, et al.
Publicado: (2023)

Protective Effects of the Key Compounds Isolated from Corni fructus against β-Amyloid-Induced Neurotoxicity in PC12 Cells
por: Hong, Seung-Young, et al.
Publicado: (2012)

Pharmacokinetics of ligustrazine ethosome patch in rats and anti-myocardial ischemia and anti-ischemic reperfusion injury effect
por: Liu, Xingyan, et al.
Publicado: (2011)

Ligustrazine Exerts Cardioprotection in Animal Models of Myocardial Ischemia/Reperfusion Injury: Preclinical Evidence and Possible Mechanisms
por: Zheng, Qun, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_7uhlnegum2piui4ans32tjmvsm