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New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix
Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison,...
| Autores principales: | , , , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
MDPI
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613290/ https://www.ncbi.nlm.nih.gov/pubmed/26378524 http://dx.doi.org/10.3390/ijms160921950 |
| _version_ | 1782396252405628928 |
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| author | Lai, Ya-Yuan Chen, Li-Chai Wu, Chug-Fung Lu, Mei-Chin Wen, Zhi-Hong Wu, Tung-Ying Fang, Lee-Shing Wang, Li-Hsueh Wu, Yang-Chang Sung, Ping-Jyun |
| author_facet | Lai, Ya-Yuan Chen, Li-Chai Wu, Chug-Fung Lu, Mei-Chin Wen, Zhi-Hong Wu, Tung-Ying Fang, Lee-Shing Wang, Li-Hsueh Wu, Yang-Chang Sung, Ping-Jyun |
| author_sort | Lai, Ya-Yuan |
| collection | PubMed |
| description | Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC(50) ≤ 5.0 μM). |
| format | Online Article Text |
| id | pubmed-4613290 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | MDPI |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46132902015-10-26 New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix Lai, Ya-Yuan Chen, Li-Chai Wu, Chug-Fung Lu, Mei-Chin Wen, Zhi-Hong Wu, Tung-Ying Fang, Lee-Shing Wang, Li-Hsueh Wu, Yang-Chang Sung, Ping-Jyun Int J Mol Sci Article Two new 24-homoscalarane sesterterpenoids, felixins F (1) and G (2), were isolated from the sponge Ircinia felix. The structures of new homoscalaranes 1 and 2 were elucidated by extensive spectroscopic methods, particularly with one-dimensional (1D) and two-dimensional (2D) NMR, and, by comparison, the spectral data with those of known analogues. The cytotoxicity of 1 and 2 against the proliferation of a limited panel of tumor cell lines was evaluated and 1 was found to show cytotoxicity toward the leukemia K562, MOLT-4, and SUP-T1 cells (IC(50) ≤ 5.0 μM). MDPI 2015-09-11 /pmc/articles/PMC4613290/ /pubmed/26378524 http://dx.doi.org/10.3390/ijms160921950 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/). |
| spellingShingle | Article Lai, Ya-Yuan Chen, Li-Chai Wu, Chug-Fung Lu, Mei-Chin Wen, Zhi-Hong Wu, Tung-Ying Fang, Lee-Shing Wang, Li-Hsueh Wu, Yang-Chang Sung, Ping-Jyun New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title | New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title_full | New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title_fullStr | New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title_full_unstemmed | New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title_short | New Cytotoxic 24-Homoscalarane Sesterterpenoids from the Sponge Ircinia felix |
| title_sort | new cytotoxic 24-homoscalarane sesterterpenoids from the sponge ircinia felix |
| topic | Article |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613290/ https://www.ncbi.nlm.nih.gov/pubmed/26378524 http://dx.doi.org/10.3390/ijms160921950 |
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