The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review

The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepato...

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Autores principales: Wang, Xuanbin, Xiang, Longchao, Li, Hongliang, Chen, Ping, Feng, Yibin, Zhang, Jingxuan, Yang, Nian, Li, Fei, Wang, Ye, Zhang, Quifang, Li, Fang, Cao, Fengjun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2015
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613322/
https://www.ncbi.nlm.nih.gov/pubmed/26393575
http://dx.doi.org/10.3390/ijms160922527
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author Wang, Xuanbin
Xiang, Longchao
Li, Hongliang
Chen, Ping
Feng, Yibin
Zhang, Jingxuan
Yang, Nian
Li, Fei
Wang, Ye
Zhang, Quifang
Li, Fang
Cao, Fengjun
author_facet Wang, Xuanbin
Xiang, Longchao
Li, Hongliang
Chen, Ping
Feng, Yibin
Zhang, Jingxuan
Yang, Nian
Li, Fei
Wang, Ye
Zhang, Quifang
Li, Fang
Cao, Fengjun
author_sort Wang, Xuanbin
collection PubMed
description The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study.
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spelling pubmed-46133222015-10-26 The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review Wang, Xuanbin Xiang, Longchao Li, Hongliang Chen, Ping Feng, Yibin Zhang, Jingxuan Yang, Nian Li, Fei Wang, Ye Zhang, Quifang Li, Fang Cao, Fengjun Int J Mol Sci Review The story of high mobility group protein B1 (HMGB1) in cancer is complicated and the function of HMGB1 in different cancers is uncertain. This review aims to retrieve literature regarding HMGB1 from English electronic resources, analyze and summarize the role of the HMGB1 signaling pathway in hepatocellular carcinoma (HCC), and provide useful information for carcinogenesis and progression of HCC. Results showed that HMGB1 could induce cell proliferation, differentiation, cell death, angiogenesis, metastasis, inflammation, and enhance immunofunction in in vitro and in vivo HCC models. HMGB1 and its downstream receptors RAGE, TLRs and TREM-1 may be potential anticancer targets. In conclusion, HMGB1 plays an important role in oncogenesis and represents a novel therapeutic target, which deserves further study. MDPI 2015-09-17 /pmc/articles/PMC4613322/ /pubmed/26393575 http://dx.doi.org/10.3390/ijms160922527 Text en © 2015 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Wang, Xuanbin
Xiang, Longchao
Li, Hongliang
Chen, Ping
Feng, Yibin
Zhang, Jingxuan
Yang, Nian
Li, Fei
Wang, Ye
Zhang, Quifang
Li, Fang
Cao, Fengjun
The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title_full The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title_fullStr The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title_full_unstemmed The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title_short The Role of HMGB1 Signaling Pathway in the Development and Progression of Hepatocellular Carcinoma: A Review
title_sort role of hmgb1 signaling pathway in the development and progression of hepatocellular carcinoma: a review
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613322/
https://www.ncbi.nlm.nih.gov/pubmed/26393575
http://dx.doi.org/10.3390/ijms160922527
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