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The role of chordin fragments generated by partial tolloid cleavage in regulating BMP activity

Chordin-mediated regulation of bone morphogenetic protein (BMP) family growth factors is essential in early embryogenesis and adult homoeostasis. Chordin binds to BMPs through cysteine-rich von Willebrand factor type C (vWC) homology domains and blocks them from interacting with their cell surface r...

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Detalles Bibliográficos
Autores principales: Troilo, Helen, Barrett, Anne L., Wohl, Alexander P., Jowitt, Thomas A., Collins, Richard F., Bayley, Christopher P., Zuk, Alexandra V., Sengle, Gerhard, Baldock, Clair
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613500/
https://www.ncbi.nlm.nih.gov/pubmed/26517884
http://dx.doi.org/10.1042/BST20150071