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Protein kinase C in cellular transformation: a valid target for therapy?

The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the f...

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Detalles Bibliográficos
Autores principales: Tarafdar, Anuradha, Michie, Alison M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2014
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613511/
https://www.ncbi.nlm.nih.gov/pubmed/25399570
http://dx.doi.org/10.1042/BST20140255
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author Tarafdar, Anuradha
Michie, Alison M.
author_facet Tarafdar, Anuradha
Michie, Alison M.
author_sort Tarafdar, Anuradha
collection PubMed
description The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the finding that PKC isoforms can co-operate with or antagonize other PKC family members. A number of studies suggest the involvement of PKC family members in regulating leukaemic cell survival and proliferation. Chronic lymphocytic leukaemia (CLL), the most common leukaemia in the Western world, exhibits dysregulated expression of PKC isoforms, with recent reports indicating that PKCβ and δ play a critical role in B-cell development, due to their ability to link the B-cell receptor (BCR) with downstream signalling pathways. Given the prognostic significance of the BCR in CLL, inhibition of these BCR/PKC-mediated signalling pathways is of therapeutic relevance. The present review discusses the emerging role of PKC isoforms in the pathophysiology of CLL and assesses approaches that have been undertaken to modulate PKC activity.
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spelling pubmed-46135112015-10-23 Protein kinase C in cellular transformation: a valid target for therapy? Tarafdar, Anuradha Michie, Alison M. Biochem Soc Trans Biochemical Society Focused Meetings The protein kinase C (PKC) family of serine/threonine protein kinases share structural homology, while exhibiting substantial functional diversity. PKC isoforms are ubiquitously expressed in tissues which makes it difficult to define roles for individual isoforms, with complexity compounded by the finding that PKC isoforms can co-operate with or antagonize other PKC family members. A number of studies suggest the involvement of PKC family members in regulating leukaemic cell survival and proliferation. Chronic lymphocytic leukaemia (CLL), the most common leukaemia in the Western world, exhibits dysregulated expression of PKC isoforms, with recent reports indicating that PKCβ and δ play a critical role in B-cell development, due to their ability to link the B-cell receptor (BCR) with downstream signalling pathways. Given the prognostic significance of the BCR in CLL, inhibition of these BCR/PKC-mediated signalling pathways is of therapeutic relevance. The present review discusses the emerging role of PKC isoforms in the pathophysiology of CLL and assesses approaches that have been undertaken to modulate PKC activity. Portland Press Ltd. 2014-11-17 2014-12-01 /pmc/articles/PMC4613511/ /pubmed/25399570 http://dx.doi.org/10.1042/BST20140255 Text en © The Authors Journal compilation © 2014 Biochemical Society http://creativecommons.org/licenses/by/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Licence (CC-BY) (http://creativecommons.org/licenses/by/3.0/) which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited.
spellingShingle Biochemical Society Focused Meetings
Tarafdar, Anuradha
Michie, Alison M.
Protein kinase C in cellular transformation: a valid target for therapy?
title Protein kinase C in cellular transformation: a valid target for therapy?
title_full Protein kinase C in cellular transformation: a valid target for therapy?
title_fullStr Protein kinase C in cellular transformation: a valid target for therapy?
title_full_unstemmed Protein kinase C in cellular transformation: a valid target for therapy?
title_short Protein kinase C in cellular transformation: a valid target for therapy?
title_sort protein kinase c in cellular transformation: a valid target for therapy?
topic Biochemical Society Focused Meetings
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613511/
https://www.ncbi.nlm.nih.gov/pubmed/25399570
http://dx.doi.org/10.1042/BST20140255
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