A non-canonical ESCRT pathway, including histidine domain phosphotyrosine phosphatase (HD-PTP), is used for down-regulation of virally ubiquitinated MHC class I

The Kaposi's sarcoma-associated herpes virus (KSHV) K3 viral gene product effectively down-regulates cell surface MHC class I. K3 is an E3 ubiquitin ligase that promotes Lys(63)-linked polyubiquitination of MHC class I, providing the signal for clathrin-mediated endocytosis. Endocytosis is foll...

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Detalles Bibliográficos
Autores principales: Parkinson, Michael D.J., Piper, Siân C., Bright, Nicholas A., Evans, Jennifer L., Boname, Jessica M., Bowers, Katherine, Lehner, Paul J., Luzio, J. Paul
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613529/
https://www.ncbi.nlm.nih.gov/pubmed/26221024
http://dx.doi.org/10.1042/BJ20150336

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