Cargando…

High homocysteine induces betaine depletion

Betaine is the substrate of the liver- and kidney-specific betaine-homocysteine (Hcy) methyltransferase (BHMT), an alternate pathway for Hcy remethylation. We hypothesized that BHMT is a major pathway for homocysteine removal in cases of hyperhomocysteinaemia (HHcy). Therefore, we measured betaine i...

Descripción completa

Detalles Bibliográficos
Autores principales:	Imbard, Apolline, Benoist, Jean-François, Esse, Ruben, Gupta, Sapna, Lebon, Sophie, de Vriese, An S, de Baulny, Helene Ogier, Kruger, Warren, Schiff, Manuel, Blom, Henk J.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613678/ https://www.ncbi.nlm.nih.gov/pubmed/26182429 http://dx.doi.org/10.1042/BSR20150094

Ejemplares similares

Efficacy and pharmacokinetics of betaine in CBS and cblC deficiencies: a cross-over randomized controlled trial
por: Imbard, Apolline, et al.
Publicado: (2022)

Liver and brain differential expression of one-carbon metabolism genes during ontogenesis
por: Imbard, Apolline, et al.
Publicado: (2021)

Neural Tube Defects, Folic Acid and Methylation
por: Imbard, Apolline, et al.
Publicado: (2013)

Should Metabolic Diseases Be Systematically Screened in Nonsyndromic Autism Spectrum Disorders?
por: Schiff, Manuel, et al.
Publicado: (2011)

Correction: Should Metabolic Diseases Be Systematically Screened in Nonsyndromic Autism Spectrum Disorders?
por: Schiff, Manuel, et al.
Publicado: (2011)

Diagnostic contribution of metabolic workup for neonatal inherited metabolic disorders in the absence of expanded newborn screening
por: Bower, Alexandra, et al.
Publicado: (2019)

New spastic paraplegia phenotype associated to mutation of NFU1
por: Tonduti, Davide, et al.
Publicado: (2015)

Transient neonatal renal failure and massive polyuria in MEGDEL syndrome
por: Harbulot, Carole, et al.
Publicado: (2016)

QIL1 mutation causes MICOS disassembly and early onset fatal mitochondrial encephalopathy with liver disease
por: Guarani, Virginia, et al.
Publicado: (2016)

Homocysteine Homeostasis and Betaine-Homocysteine S-Methyltransferase Expression in the Brain of Hibernating Bats
por: Zhang, Yijian, et al.
Publicado: (2013)

Determining factors of the cognitive outcome in early treated PKU: A study of 39 pediatric patients
por: Herenger, Yvan, et al.
Publicado: (2019)

Effects of betaine on body composition, performance, and homocysteine thiolactone
por: Cholewa, Jason M, et al.
Publicado: (2013)

Citrulline in the management of patients with urea cycle disorders
por: Imbard, Apolline, et al.
Publicado: (2023)

Nitrous oxide and vitamin B12 in sickle cell disease: Not a laughing situation
por: Desprairies, Camille, et al.
Publicado: (2020)

The Contribution of Homocysteine Metabolism Disruption to Endothelial Dysfunction: State-of-the-Art
por: Esse, Ruben, et al.
Publicado: (2019)

The homocysteine controversy
por: Smulders, Yvo M., et al.
Publicado: (2010)

Identification of hepatic protein-protein interaction targets for betaine homocysteine S-methyltransferase
por: Garrido, Francisco, et al.
Publicado: (2018)

The Metabolic Burden of Methyl Donor Deficiency with Focus on the Betaine Homocysteine Methyltransferase Pathway
por: Obeid, Rima
Publicado: (2013)

Evolutionary Analyses and Natural Selection of Betaine-Homocysteine S-Methyltransferase (BHMT) and BHMT2 Genes
por: Ganu, Radhika S., et al.
Publicado: (2015)

Foreword to special issue on homocysteine disorders
por: Fowler, Brian, et al.
Publicado: (2011)

Homocysteine modulates 5‐lipoxygenase expression level via DNA methylation
por: Li, Jian‐Guo, et al.
Publicado: (2016)

Cystathionine beta synthase deficiency and brain edema associated with methionine excess under betaine supplementation: Four new cases and a review of the evidence
por: Schwahn, Bernd C., et al.
Publicado: (2020)

The Contrasting Relationships between Betaine and Homocysteine in Two Clinical Cohorts are Associated with Plasma Lipids and Drug Treatments
por: Lever, Michael, et al.
Publicado: (2012)

Overview of homocysteine and folate metabolism. With special references to cardiovascular disease and neural tube defects
por: Blom, Henk J., et al.
Publicado: (2010)

Folinic Acid Increases Protein Arginine Methylation in Human Endothelial Cells
por: Esse, Ruben, et al.
Publicado: (2018)

Cystathionine beta-synthase null homocystinuric mice fail to exhibit altered hemostasis or lowering of plasma homocysteine in response to betaine treatment
por: Maclean, Kenneth N., et al.
Publicado: (2010)

Homocysteine and Familial Longevity: The Leiden Longevity Study
por: Wijsman, Carolien A., et al.
Publicado: (2011)

The betaine/GABA transporter and betaine: roles in brain, kidney, and liver
por: Kempson, Stephen A., et al.
Publicado: (2014)

Homocysteine Levels and Treatment Effect in the Prospective Study of Pravastatin in the Elderly at Risk
por: Drewes, Yvonne M, et al.
Publicado: (2014)

Recommendations for the management of tyrosinaemia type 1
por: de Laet, Corinne, et al.
Publicado: (2013)

Betaine anhydrous in homocystinuria: results from the RoCH registry
por: Valayannopoulos, Vassili, et al.
Publicado: (2019)

Stability of Betaine Capsules
por: Hossain, Mirza Akram, et al.
Publicado: (2013)

Comparing effects of natural betaine and betaine hydrochloride on gut physiology in broiler chickens
por: Awad, Wageha A., et al.
Publicado: (2022)

Effect of Folic Acid, Betaine, Vitamin B(6), and Vitamin B(12) on Homocysteine and Dimethylglycine Levels in Middle-Aged Men Drinking White Wine
por: Rajdl, Daniel, et al.
Publicado: (2016)

Association of Plasma Folate, Vitamin B12, and Betaine With Total Homocysteine in Pregnancy, and Effect Modification Due to Folic Acid Versus Natural Folate Supplementation
por: Cochrane, Kelsey, et al.
Publicado: (2022)

Initial presentation, management and follow-up data of 33 treated patients with hereditary tyrosinemia type 1 in the absence of newborn screening
por: Hajji, Hela, et al.
Publicado: (2022)

No Effect of Folic Acid Supplementation on Global DNA Methylation in Men and Women with Moderately Elevated Homocysteine
por: Jung, Audrey Y., et al.
Publicado: (2011)

The Compartmentalisation of Phosphorylated Free Oligosaccharides in Cells from a CDG Ig Patient Reveals a Novel ER-to-Cytosol Translocation Process
por: Peric, Delphine, et al.
Publicado: (2010)

High Betaine and Dynamic Increase of Betaine Levels Are Both Associated With Poor Prognosis of Patients With Pulmonary Hypertension
por: Yang, Yicheng, et al.
Publicado: (2022)

Effect of betaine on cycling sprint power
por: Czapla, Riana, et al.
Publicado: (2010)

Cannot write session to /tmp/vufind_sessions/sess_5afotlmq6g2m9cs0q9tf17vmdq