Cargando…

Human exonuclease 1 (EXO1) activity characterization and its function on flap structures

Human exonuclease 1 (EXO1) is involved in multiple DNA metabolism processes, including DNA repair and replication. Most of the fundamental roles of EXO1 have been described in yeast. Here, we report a biochemical characterization of human full-length EXO1. Prior to assay EXO1 on different DNA flap s...

Descripción completa

Detalles Bibliográficos
Autores principales:	Keijzers, Guido, Bohr, Vilhelm A., Rasmussen, Lene Juel
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Portland Press Ltd. 2015
Materias:	Original Papers
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613700/ https://www.ncbi.nlm.nih.gov/pubmed/26182368 http://dx.doi.org/10.1042/BSR20150058

Ejemplares similares

Human Exonuclease 1 (EXO1) Regulatory Functions in DNA Replication with Putative Roles in Cancer
por: Keijzers, Guido, et al.
Publicado: (2018)

Nuclear localization of human DNA mismatch repair protein exonuclease 1 (hEXO1)
por: Knudsen, Nina Østergaard, et al.
Publicado: (2007)

The helicase and ATPase activities of RECQL4 are compromised by mutations reported in three human patients
por: Jensen, Martin Borch, et al.
Publicado: (2012)

ExoMeg1: a new exonuclease from metagenomic library
por: Silva-Portela, Rita C. B., et al.
Publicado: (2016)

Mrc1 protects uncapped budding yeast telomeres from exonuclease EXO1
por: Tsolou, Avgi, et al.
Publicado: (2007)

Interaction between RECQL4 and OGG1 promotes repair of oxidative base lesion 8-oxoG and is regulated by SIRT1 deacetylase
por: Duan, Shunlei, et al.
Publicado: (2020)

Cytosolic Self-DNA—A Potential Source of Chronic Inflammation in Aging
por: Akbari, Mansour, et al.
Publicado: (2021)

Increased deoxythymidine triphosphate levels is a feature of relative cognitive decline
por: Desler, Claus, et al.
Publicado: (2015)

DNA damage response, bioenergetics, and neurological disease: The challenge of maintaining brain health in an aging human(,,)
por: Rasmussen, Lene Juel, et al.
Publicado: (2013)

Exonuclease 1 (EXO1) is a Potential Prognostic Biomarker and Correlates with Immune Infiltrates in Lung Adenocarcinoma
por: Zhou, Chang-shuai, et al.
Publicado: (2021)

Structural basis for substrate recognition and processive cleavage mechanisms of the trimeric exonuclease PhoExo I
por: Miyazono, Ken-ichi, et al.
Publicado: (2015)

Relationships between human vitality and mitochondrial respiratory parameters, reactive oxygen species production and dNTP levels in peripheral blood mononuclear cells
por: Maynard, Scott, et al.
Publicado: (2013)

Molecular interactions of Escherichia coli ExoIX and identification of its associated 3′–5′ exonuclease activity
por: Hodskinson, Michael R. G., et al.
Publicado: (2007)

Exonuclease 1 (Exo1) Participates in Mammalian Non-Homologous End Joining and Contributes to Drug Resistance in Ovarian Cancer
por: He, Dongyun, et al.
Publicado: (2020)

The Role of Exo1p Exonuclease in DNA End Resection to Generate Gene Conversion Tracts in Saccharomyces cerevisiae
por: Yin, Yi, et al.
Publicado: (2014)

The WRN exonuclease domain protects nascent strands from pathological MRE11/EXO1-dependent degradation
por: Iannascoli, Chiara, et al.
Publicado: (2015)

WRN Exonuclease activity is blocked by specific oxidatively induced base lesions positioned in either DNA strand
por: Bukowy, Zuzanna, et al.
Publicado: (2008)

Defective mitochondrial respiration, altered dNTP pools and reduced AP endonuclease 1 activity in peripheral blood mononuclear cells of Alzheimer's disease patients
por: Maynard, Scott, et al.
Publicado: (2015)

Recognition and processing of double-stranded DNA by ExoX, a distributive 3′–5′ exonuclease
por: Wang, Tianyu, et al.
Publicado: (2013)

A unique exonuclease ExoG cleaves between RNA and DNA in mitochondrial DNA replication
por: Wu, Chyuan-Chuan, et al.
Publicado: (2019)

Distinct Activities of Exonuclease 1 and Flap Endonuclease 1 at Telomeric G4 DNA
por: Vallur, Aarthy C., et al.
Publicado: (2010)

Human RECQL5β stimulates flap endonuclease 1
por: Speina, Elżbieta, et al.
Publicado: (2010)

Human DNA polymerase delta double-mutant D316A;E318A interferes with DNA mismatch repair in vitro
por: Liu, Dekang, et al.
Publicado: (2017)

Exo1 phosphorylation inhibits exonuclease activity and prevents fork collapse in rad53 mutants independently of the 14-3-3 proteins
por: Morafraile, Esther C, et al.
Publicado: (2020)

Symmetric activity of DNA polymerases at and recruitment of exonuclease ExoR and of PolA to the Bacillus subtilis replication forks
por: Hernández-Tamayo, Rogelio, et al.
Publicado: (2019)

Understanding APE1 cellular functions by the structural preference of exonuclease activities
por: Liu, Tung-Chang, et al.
Publicado: (2021)

Phosphorylation of human oxoguanine DNA glycosylase (α-OGG1) modulates its function
por: Hu, Jingping, et al.
Publicado: (2005)

The Population Structure of Pseudomonas aeruginosa Is Characterized by Genetic Isolation of exoU+ and exoS+ Lineages
por: Ozer, Egon A, et al.
Publicado: (2019)

Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2017)

The 5′-phosphate enhances the DNA-binding and exonuclease activities of human mitochondrial genome maintenance exonuclease 1 (MGME1)
por: Urrutia, Kathleen M., et al.
Publicado: (2022)

Author Correction: Rev1 contributes to proper mitochondrial function via the PARP-NAD(+)-SIRT1-PGC1α axis
por: Fakouri, Nima Borhan, et al.
Publicado: (2018)

Characterization of the Human SNM1A and SNM1B/Apollo DNA Repair Exonucleases
por: Sengerová, Blanka, et al.
Publicado: (2012)

The structure of Escherichia coli ExoIX—implications for DNA binding and catalysis in flap endonucleases
por: Anstey-Gilbert, Christopher S., et al.
Publicado: (2013)

Expression, purification, and characterization of the recombinant exo-1,3-β-glucanase (Exo1) of the pathogenic oomycete Pythium insidiosum
por: Rotchanapreeda, Tiwa, et al.
Publicado: (2020)

Structure and function of TatD exonuclease in DNA repair
por: Chen, Yi-Chen, et al.
Publicado: (2014)

Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD(+) precursor nicotinamide riboside
por: Anugula, Sharath, et al.
Publicado: (2023)

ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes
por: Wang, Hailong, et al.
Publicado: (2018)

ExoCET: exonuclease in vitro assembly combined with RecET recombination for highly efficient direct DNA cloning from complex genomes
por: Wang, Hailong, et al.
Publicado: (2018)

The DNA structure and sequence preferences of WRN underlie its function in telomeric recombination events
por: Edwards, Deanna N., et al.
Publicado: (2015)

Biochemical characterization of a cancer-associated E109K missense variant of human exonuclease 1
por: Bregenhorn, Stephanie, et al.
Publicado: (2014)

Cannot write session to /tmp/vufind_sessions/sess_ebkknokbd33d3t0uskh5a59o7d