Identification of residues in ABCG2 affecting protein trafficking and drug transport, using co-evolutionary analysis of ABCG sequences

ABCG2 is an ABC (ATP-binding cassette) transporter with a physiological role in urate transport in the kidney and is also implicated in multi-drug efflux from a number of organs in the body. The trafficking of the protein and the mechanism by which it recognizes and transports diverse drugs are impo...

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Detalles Bibliográficos
Autores principales: Haider, Ameena J., Cox, Megan H., Jones, Natalie, Goode, Alice J., Bridge, Katherine S., Wong, Kelvin, Briggs, Deborah, Kerr, Ian D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613716/
https://www.ncbi.nlm.nih.gov/pubmed/26294421
http://dx.doi.org/10.1042/BSR20150150

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