Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads

Saliva diagnostics utilizing nanotechnology and molecular technologies to detect oral squamous cell carcinoma (OSCC) has become an attractive field of study. However, no specific methods have been established. To refine the diagnostic power of saliva peptide fingerprints for the early detection of O...

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Detalles Bibliográficos
Autores principales: Jiang, Wei-Peng, Wang, Zhen, Xu, Li-Xin, Peng, Xin, Chen, Feng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Portland Press Ltd. 2015
Materias:
Original Papers
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613719/
https://www.ncbi.nlm.nih.gov/pubmed/26182373
http://dx.doi.org/10.1042/BSR20150023
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author Jiang, Wei-Peng
Wang, Zhen
Xu, Li-Xin
Peng, Xin
Chen, Feng
author_facet Jiang, Wei-Peng
Wang, Zhen
Xu, Li-Xin
Peng, Xin
Chen, Feng
author_sort Jiang, Wei-Peng
collection PubMed
description Saliva diagnostics utilizing nanotechnology and molecular technologies to detect oral squamous cell carcinoma (OSCC) has become an attractive field of study. However, no specific methods have been established. To refine the diagnostic power of saliva peptide fingerprints for the early detection of OSCC, we screened the expression spectrum of salivary peptides in 40 T1 stage OSCC patients (and healthy controls) using MALDI-TOF-MS combined with magnetic beads. Fifty proteins showed significantly different expression levels in the OSCC samples (P<0.05). Potential biomarkers were also predicted. The novel diagnostic proteomic model with m/z peaks of 1285.6 Da and 1432.2 Da are of certain value for early diagnosis of OSCC.
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spelling pubmed-46137192016-09-13 Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads Jiang, Wei-Peng Wang, Zhen Xu, Li-Xin Peng, Xin Chen, Feng Biosci Rep Original Papers Saliva diagnostics utilizing nanotechnology and molecular technologies to detect oral squamous cell carcinoma (OSCC) has become an attractive field of study. However, no specific methods have been established. To refine the diagnostic power of saliva peptide fingerprints for the early detection of OSCC, we screened the expression spectrum of salivary peptides in 40 T1 stage OSCC patients (and healthy controls) using MALDI-TOF-MS combined with magnetic beads. Fifty proteins showed significantly different expression levels in the OSCC samples (P<0.05). Potential biomarkers were also predicted. The novel diagnostic proteomic model with m/z peaks of 1285.6 Da and 1432.2 Da are of certain value for early diagnosis of OSCC. Portland Press Ltd. 2015-06-22 /pmc/articles/PMC4613719/ /pubmed/26182373 http://dx.doi.org/10.1042/BSR20150023 Text en © 2015 The Authors http://creativecommons.org/licenses/by/3.0/ This is an open access article published by Portland Press Limited and distributed under the Creative Commons Attribution License 3.0. (http://creativecommons.org/licenses/by/3.0/)
spellingShingle Original Papers
Jiang, Wei-Peng
Wang, Zhen
Xu, Li-Xin
Peng, Xin
Chen, Feng
Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title_full Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title_fullStr Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title_full_unstemmed Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title_short Diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
title_sort diagnostic model of saliva peptide finger print analysis of oral squamous cell carcinoma patients using weak cation exchange magnetic beads
topic Original Papers
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613719/
https://www.ncbi.nlm.nih.gov/pubmed/26182373
http://dx.doi.org/10.1042/BSR20150023
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