Immortalization of normal human mammary epithelial cells in two steps by direct targeting of senescence barriers does not require gross genomic alterations

Telomerase reactivation and immortalization are critical for human carcinoma progression. However, little is known about the mechanisms controlling this crucial step, due in part to the paucity of experimentally tractable model systems that can examine human epithelial cell immortalization as it mig...

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Detalles Bibliográficos
Autores principales: Garbe, James C, Vrba, Lukas, Sputova, Klara, Fuchs, Laura, Novak, Petr, Brothman, Arthur R, Jackson, Mark, Chin, Koei, LaBarge, Mark A, Watts, George, Futscher, Bernard W, Stampfer, Martha R
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2014
Materias:
Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613853/
https://www.ncbi.nlm.nih.gov/pubmed/25485586
http://dx.doi.org/10.4161/15384101.2014.954456

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