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A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells

Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes f...

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Autores principales: Chandran, Yogeswari, Kang, Nam-Young, Park, Sung-Jin, Husen Alamudi, Samira, Kim, Jun-Young, Sahu, Srikanta, Su, Dongdong, Lee, Jungyeol, Vendrell, Marc, Chang, Young-Tae
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier Science Ltd 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613884/
https://www.ncbi.nlm.nih.gov/pubmed/26115574
http://dx.doi.org/10.1016/j.bmcl.2015.06.037
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author Chandran, Yogeswari
Kang, Nam-Young
Park, Sung-Jin
Husen Alamudi, Samira
Kim, Jun-Young
Sahu, Srikanta
Su, Dongdong
Lee, Jungyeol
Vendrell, Marc
Chang, Young-Tae
author_facet Chandran, Yogeswari
Kang, Nam-Young
Park, Sung-Jin
Husen Alamudi, Samira
Kim, Jun-Young
Sahu, Srikanta
Su, Dongdong
Lee, Jungyeol
Vendrell, Marc
Chang, Young-Tae
author_sort Chandran, Yogeswari
collection PubMed
description Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities.
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spelling pubmed-46138842015-11-10 A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells Chandran, Yogeswari Kang, Nam-Young Park, Sung-Jin Husen Alamudi, Samira Kim, Jun-Young Sahu, Srikanta Su, Dongdong Lee, Jungyeol Vendrell, Marc Chang, Young-Tae Bioorg Med Chem Lett Article Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities. Elsevier Science Ltd 2015-11-01 /pmc/articles/PMC4613884/ /pubmed/26115574 http://dx.doi.org/10.1016/j.bmcl.2015.06.037 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Chandran, Yogeswari
Kang, Nam-Young
Park, Sung-Jin
Husen Alamudi, Samira
Kim, Jun-Young
Sahu, Srikanta
Su, Dongdong
Lee, Jungyeol
Vendrell, Marc
Chang, Young-Tae
A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title_full A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title_fullStr A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title_full_unstemmed A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title_short A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
title_sort highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613884/
https://www.ncbi.nlm.nih.gov/pubmed/26115574
http://dx.doi.org/10.1016/j.bmcl.2015.06.037
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