Cargando…
A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells
Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes f...
Autores principales: | , , , , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier Science Ltd
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613884/ https://www.ncbi.nlm.nih.gov/pubmed/26115574 http://dx.doi.org/10.1016/j.bmcl.2015.06.037 |
_version_ | 1782396334144225280 |
---|---|
author | Chandran, Yogeswari Kang, Nam-Young Park, Sung-Jin Husen Alamudi, Samira Kim, Jun-Young Sahu, Srikanta Su, Dongdong Lee, Jungyeol Vendrell, Marc Chang, Young-Tae |
author_facet | Chandran, Yogeswari Kang, Nam-Young Park, Sung-Jin Husen Alamudi, Samira Kim, Jun-Young Sahu, Srikanta Su, Dongdong Lee, Jungyeol Vendrell, Marc Chang, Young-Tae |
author_sort | Chandran, Yogeswari |
collection | PubMed |
description | Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities. |
format | Online Article Text |
id | pubmed-4613884 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Elsevier Science Ltd |
record_format | MEDLINE/PubMed |
spelling | pubmed-46138842015-11-10 A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells Chandran, Yogeswari Kang, Nam-Young Park, Sung-Jin Husen Alamudi, Samira Kim, Jun-Young Sahu, Srikanta Su, Dongdong Lee, Jungyeol Vendrell, Marc Chang, Young-Tae Bioorg Med Chem Lett Article Stem cell research has gathered immense attention in the past decade due to the remarkable ability of stem cells for self-renewal and tissue-specific differentiation. Despite having numerous advancements in stem cell isolation and manipulation techniques, there is a need for highly reliable probes for the specific detection of live stem cells. Herein we developed a new fluorescence probe (CDy9) with high selectivity for mouse embryonic stem cells. CDy9 allows the detection and isolation of intact stem cells with marginal impact on their function and capabilities. Elsevier Science Ltd 2015-11-01 /pmc/articles/PMC4613884/ /pubmed/26115574 http://dx.doi.org/10.1016/j.bmcl.2015.06.037 Text en © 2015 The Authors http://creativecommons.org/licenses/by/4.0/ This is an open access article under the CC BY license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article Chandran, Yogeswari Kang, Nam-Young Park, Sung-Jin Husen Alamudi, Samira Kim, Jun-Young Sahu, Srikanta Su, Dongdong Lee, Jungyeol Vendrell, Marc Chang, Young-Tae A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title | A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title_full | A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title_fullStr | A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title_full_unstemmed | A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title_short | A highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
title_sort | highly selective fluorescent probe for direct detection and isolation of mouse embryonic stem cells |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613884/ https://www.ncbi.nlm.nih.gov/pubmed/26115574 http://dx.doi.org/10.1016/j.bmcl.2015.06.037 |
work_keys_str_mv | AT chandranyogeswari ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT kangnamyoung ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT parksungjin ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT husenalamudisamira ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT kimjunyoung ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT sahusrikanta ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT sudongdong ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT leejungyeol ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT vendrellmarc ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT changyoungtae ahighlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT chandranyogeswari highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT kangnamyoung highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT parksungjin highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT husenalamudisamira highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT kimjunyoung highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT sahusrikanta highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT sudongdong highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT leejungyeol highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT vendrellmarc highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells AT changyoungtae highlyselectivefluorescentprobefordirectdetectionandisolationofmouseembryonicstemcells |