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Elevations in Circulating Methylated and Unmethylated Preproinsulin DNA in New-Onset Type 1 Diabetes
Elevated ratios of circulating unmethylated to methylated preproinsulin (INS) DNA have been suggested to reflect β-cell death in type 1 diabetes (T1D). We tested the hypothesis that absolute levels (rather than ratios) of unmethylated and methylated INS DNA differ between subjects with new-onset T1D...
Autores principales: | Fisher, Marisa M., Watkins, Renecia A., Blum, Janice, Evans-Molina, Carmella, Chalasani, Naga, DiMeglio, Linda A., Mather, Kieren J., Tersey, Sarah A., Mirmira, Raghavendra G. |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Diabetes Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613977/ https://www.ncbi.nlm.nih.gov/pubmed/26216854 http://dx.doi.org/10.2337/db15-0430 |
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