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β-Cell MicroRNAs: Small but Powerful

Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of...

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Detalles Bibliográficos
Autores principales: Filios, Stephen R., Shalev, Anath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Diabetes Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613982/
https://www.ncbi.nlm.nih.gov/pubmed/26494215
http://dx.doi.org/10.2337/db15-0831
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author Filios, Stephen R.
Shalev, Anath
author_facet Filios, Stephen R.
Shalev, Anath
author_sort Filios, Stephen R.
collection PubMed
description Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of genes and pathways potentially affected is huge. Not surprisingly, many miRs have also been implicated in diabetes, and more recently, some have been discovered to play important roles in the pancreatic islet, including β-cell function, proliferation, and survival. The goal of this Perspective is to offer an overview of this rapidly evolving field and the miRs involved, reveal novel networks of β-cell miR signaling, and provide an outlook of the opportunities and challenges ahead.
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spelling pubmed-46139822016-11-01 β-Cell MicroRNAs: Small but Powerful Filios, Stephen R. Shalev, Anath Diabetes Perspectives in Diabetes Noncoding RNA and especially microRNAs (miRs) have emerged as important regulators of key processes in cell biology, including development, differentiation, and survival. Currently, over 2,500 mature miRs have been reported in humans, and considering that each miR has multiple targets, the number of genes and pathways potentially affected is huge. Not surprisingly, many miRs have also been implicated in diabetes, and more recently, some have been discovered to play important roles in the pancreatic islet, including β-cell function, proliferation, and survival. The goal of this Perspective is to offer an overview of this rapidly evolving field and the miRs involved, reveal novel networks of β-cell miR signaling, and provide an outlook of the opportunities and challenges ahead. American Diabetes Association 2015-11 2015-10-14 /pmc/articles/PMC4613982/ /pubmed/26494215 http://dx.doi.org/10.2337/db15-0831 Text en © 2015 by the American Diabetes Association. Readers may use this article as long as the work is properly cited, the use is educational and not for profit, and the work is not altered.
spellingShingle Perspectives in Diabetes
Filios, Stephen R.
Shalev, Anath
β-Cell MicroRNAs: Small but Powerful
title β-Cell MicroRNAs: Small but Powerful
title_full β-Cell MicroRNAs: Small but Powerful
title_fullStr β-Cell MicroRNAs: Small but Powerful
title_full_unstemmed β-Cell MicroRNAs: Small but Powerful
title_short β-Cell MicroRNAs: Small but Powerful
title_sort β-cell micrornas: small but powerful
topic Perspectives in Diabetes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4613982/
https://www.ncbi.nlm.nih.gov/pubmed/26494215
http://dx.doi.org/10.2337/db15-0831
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