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AMPK-HDAC5 pathway facilitates nuclear accumulation of HIF-1α and functional activation of HIF-1 by deacetylating Hsp70 in the cytosol

Hypoxia-inducible factor 1 (HIF-1) transcriptionally promotes production of adenosine triphosphate (ATP) whereas AMPK senses and regulates cellular energy homeostasis. A histone deacetylase (HDAC) activity has been proven to be critical for HIF-1 activation but the underlying mechanism and its role...

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Detalles Bibliográficos
Autores principales:	Chen, Shuyang, Yin, Chengqian, Lao, Taotao, Liang, Dongming, He, Dan, Wang, Chenguang, Sang, Nianli
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2015
Materias:	Report
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614078/ https://www.ncbi.nlm.nih.gov/pubmed/26061431 http://dx.doi.org/10.1080/15384101.2015.1055426

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