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An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression
A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the ches...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614185/ https://www.ncbi.nlm.nih.gov/pubmed/25381826 http://dx.doi.org/10.4143/crt.2014.016 |
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author | Kang, Hye Seon Lee, Hea Yon Kim, Seung Joon Kim, Seok Chan Kim, Young Kyoon Park, Gyeong Sin Lee, Kyo Young Jung, Jung Im Kang, Ji Young |
author_facet | Kang, Hye Seon Lee, Hea Yon Kim, Seung Joon Kim, Seok Chan Kim, Young Kyoon Park, Gyeong Sin Lee, Kyo Young Jung, Jung Im Kang, Ji Young |
author_sort | Kang, Hye Seon |
collection | PubMed |
description | A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course. |
format | Online Article Text |
id | pubmed-4614185 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-46141852015-10-22 An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression Kang, Hye Seon Lee, Hea Yon Kim, Seung Joon Kim, Seok Chan Kim, Young Kyoon Park, Gyeong Sin Lee, Kyo Young Jung, Jung Im Kang, Ji Young Cancer Res Treat Case Report A 57-year-old woman presented with cough and dyspnea for 2 months. Computed tomography of the chest showed diffuse ground-glass opacities in both lungs. Histologic examination via thoracoscopic lung biopsy revealed atypical lymphoproliferative lesion. Her symptoms and radiologic findings of the chest improved just after lung biopsy without any treatment. Therefore, she was discharged and monitored at an outpatient clinic. Two months later, pulmonary mucosa-associated lymphoid tissue (MALT) lymphoma was confirmed by the detection of API2-MALT1 translocation in fluorescent in situ hybridization analysis. Although the lung lesions resolved spontaneously, she received chemotherapy due to bone marrow involvement in her staging workup. Pulmonary MALT lymphoma is rare. Nodular or consolidative patterns are the most frequent radiologic findings. Although the disease has an indolent growth, it rarely resolves without treatment. We report an unusual case of pulmonary MALT lymphoma with diffuse interstitial abnormalities on image and spontaneous regression on clinical course. Korean Cancer Association 2015-10 2014-09-15 /pmc/articles/PMC4614185/ /pubmed/25381826 http://dx.doi.org/10.4143/crt.2014.016 Text en Copyright © 2015 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Case Report Kang, Hye Seon Lee, Hea Yon Kim, Seung Joon Kim, Seok Chan Kim, Young Kyoon Park, Gyeong Sin Lee, Kyo Young Jung, Jung Im Kang, Ji Young An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title | An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title_full | An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title_fullStr | An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title_full_unstemmed | An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title_short | An Unusual Presentation of Pulmonary Mucosa-Associated Lymphoid Tissue Lymphoma as Diffuse Pulmonary Infiltrates with Spontaneous Regression |
title_sort | unusual presentation of pulmonary mucosa-associated lymphoid tissue lymphoma as diffuse pulmonary infiltrates with spontaneous regression |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614185/ https://www.ncbi.nlm.nih.gov/pubmed/25381826 http://dx.doi.org/10.4143/crt.2014.016 |
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