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Long-term Outcome of Chondrosarcoma: A Single Institutional Experience

PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prog...

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Autores principales: Bindiganavile, Srimanth, Han, Ilkyu, Yun, Ji Yeon, Kim, Han-Soo
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Korean Cancer Association 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614192/
https://www.ncbi.nlm.nih.gov/pubmed/25687868
http://dx.doi.org/10.4143/crt.2014.135
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author Bindiganavile, Srimanth
Han, Ilkyu
Yun, Ji Yeon
Kim, Han-Soo
author_facet Bindiganavile, Srimanth
Han, Ilkyu
Yun, Ji Yeon
Kim, Han-Soo
author_sort Bindiganavile, Srimanth
collection PubMed
description PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution. RESULTS: Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. CONCLUSION: Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome.
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spelling pubmed-46141922015-10-22 Long-term Outcome of Chondrosarcoma: A Single Institutional Experience Bindiganavile, Srimanth Han, Ilkyu Yun, Ji Yeon Kim, Han-Soo Cancer Res Treat Original Article PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution. RESULTS: Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. CONCLUSION: Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome. Korean Cancer Association 2015-10 2015-02-12 /pmc/articles/PMC4614192/ /pubmed/25687868 http://dx.doi.org/10.4143/crt.2014.135 Text en Copyright © 2015 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Bindiganavile, Srimanth
Han, Ilkyu
Yun, Ji Yeon
Kim, Han-Soo
Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title_full Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title_fullStr Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title_full_unstemmed Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title_short Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
title_sort long-term outcome of chondrosarcoma: a single institutional experience
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614192/
https://www.ncbi.nlm.nih.gov/pubmed/25687868
http://dx.doi.org/10.4143/crt.2014.135
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