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Long-term Outcome of Chondrosarcoma: A Single Institutional Experience
PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prog...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Korean Cancer Association
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614192/ https://www.ncbi.nlm.nih.gov/pubmed/25687868 http://dx.doi.org/10.4143/crt.2014.135 |
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author | Bindiganavile, Srimanth Han, Ilkyu Yun, Ji Yeon Kim, Han-Soo |
author_facet | Bindiganavile, Srimanth Han, Ilkyu Yun, Ji Yeon Kim, Han-Soo |
author_sort | Bindiganavile, Srimanth |
collection | PubMed |
description | PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution. RESULTS: Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. CONCLUSION: Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome. |
format | Online Article Text |
id | pubmed-4614192 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Korean Cancer Association |
record_format | MEDLINE/PubMed |
spelling | pubmed-46141922015-10-22 Long-term Outcome of Chondrosarcoma: A Single Institutional Experience Bindiganavile, Srimanth Han, Ilkyu Yun, Ji Yeon Kim, Han-Soo Cancer Res Treat Original Article PURPOSE: The prognostic factors of chondrosarcoma remain uncertain as only a few large studies with long-term follow-up have been reported. The aim of this study was to analyze oncological outcomes and prognostic factors. MATERIALS AND METHODS: A retrospective review of oncological outcomes and prognostic factors was performed on 125 consecutive chondrosarcoma patients who underwent surgery at our institution. RESULTS: Overall survival was 91.6%±2.5%, 84.1%±3.8%, and 84.1%±3.8% at 5, 10, and 15 years respectively. Among the histological types, dedifferentiated type showed the worst survival (p < 0.001). As for conventional type chondrosarcoma, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome (p < 0.001). In contrast, low-grade chondrosarcoma of appendicular skeleton could be treated safely by intralesional curettage. CONCLUSION: Histological type was significantly associated with the outcome of chondrosarcoma. For the conventional type, histologic grade and anatomical location predicted outcome, with high-grade with axial location having the worst outcome. Korean Cancer Association 2015-10 2015-02-12 /pmc/articles/PMC4614192/ /pubmed/25687868 http://dx.doi.org/10.4143/crt.2014.135 Text en Copyright © 2015 by the Korean Cancer Association This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Original Article Bindiganavile, Srimanth Han, Ilkyu Yun, Ji Yeon Kim, Han-Soo Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title | Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title_full | Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title_fullStr | Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title_full_unstemmed | Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title_short | Long-term Outcome of Chondrosarcoma: A Single Institutional Experience |
title_sort | long-term outcome of chondrosarcoma: a single institutional experience |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614192/ https://www.ncbi.nlm.nih.gov/pubmed/25687868 http://dx.doi.org/10.4143/crt.2014.135 |
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