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Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease?
Genetic variants have been associated with the risk of coronary heart disease (CHD). Mega et al studied the association of a genetic risk score based on 27 genetic variants with incidents of recurrent CHD, adjusting for traditional risk factors using data from a community based study and 4 randomize...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Bloomsbury Qatar Foundation Journals
2015
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614335/ https://www.ncbi.nlm.nih.gov/pubmed/26535221 http://dx.doi.org/10.5339/gcsp.2015.19 |
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| author | Suwaidi, Jassim Al |
| author_facet | Suwaidi, Jassim Al |
| author_sort | Suwaidi, Jassim Al |
| collection | PubMed |
| description | Genetic variants have been associated with the risk of coronary heart disease (CHD). Mega et al studied the association of a genetic risk score based on 27 genetic variants with incidents of recurrent CHD, adjusting for traditional risk factors using data from a community based study and 4 randomized controlled trials of both primary and secondary prevention with statin therapy. When individuals were divided into low, intermediate and high genetic risk categories, a significant gradient in risk of incident and recurrent CHD was shown. |
| format | Online Article Text |
| id | pubmed-4614335 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2015 |
| publisher | Bloomsbury Qatar Foundation Journals |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46143352015-11-03 Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? Suwaidi, Jassim Al Glob Cardiol Sci Pract Lessons from the Trials Genetic variants have been associated with the risk of coronary heart disease (CHD). Mega et al studied the association of a genetic risk score based on 27 genetic variants with incidents of recurrent CHD, adjusting for traditional risk factors using data from a community based study and 4 randomized controlled trials of both primary and secondary prevention with statin therapy. When individuals were divided into low, intermediate and high genetic risk categories, a significant gradient in risk of incident and recurrent CHD was shown. Bloomsbury Qatar Foundation Journals 2015-06-22 /pmc/articles/PMC4614335/ /pubmed/26535221 http://dx.doi.org/10.5339/gcsp.2015.19 Text en © 2015 Al Suwaidi, licensee Bloomsbury Qatar Foundation Journals. This is an open access article distributed under the terms of the Creative Commons Attribution license CC BY 4.0, which permits unrestricted use, distribution and reproduction in any medium, provided the original work is properly cited. |
| spellingShingle | Lessons from the Trials Suwaidi, Jassim Al Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title | Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title_full | Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title_fullStr | Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title_full_unstemmed | Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title_short | Is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| title_sort | is there a role for genetic risk assessment in the treatment of dyslipidemia in primary and secondary prevention of coronary heart disease? |
| topic | Lessons from the Trials |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614335/ https://www.ncbi.nlm.nih.gov/pubmed/26535221 http://dx.doi.org/10.5339/gcsp.2015.19 |
| work_keys_str_mv | AT suwaidijassimal istherearoleforgeneticriskassessmentinthetreatmentofdyslipidemiainprimaryandsecondarypreventionofcoronaryheartdisease |