The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation

In infants, especially with novel previously undescribed mutations of the K(ATP) channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response...

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Autores principales: O'Connell, Susan M, Proks, Peter, Kramer, Holger, Mattis, Katia K, Sachse, Gregor, Joyce, Caroline, Houghton, Jayne A L, Ellard, Sian, Hattersley, Andrew T, Ashcroft, Frances M, O'Riordan, Stephen M P
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley & Sons, Ltd 2015
Materias:
Case Reports
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614663/
https://www.ncbi.nlm.nih.gov/pubmed/26509030
http://dx.doi.org/10.1002/ccr3.370
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author O'Connell, Susan M
Proks, Peter
Kramer, Holger
Mattis, Katia K
Sachse, Gregor
Joyce, Caroline
Houghton, Jayne A L
Ellard, Sian
Hattersley, Andrew T
Ashcroft, Frances M
O'Riordan, Stephen M P
author_facet O'Connell, Susan M
Proks, Peter
Kramer, Holger
Mattis, Katia K
Sachse, Gregor
Joyce, Caroline
Houghton, Jayne A L
Ellard, Sian
Hattersley, Andrew T
Ashcroft, Frances M
O'Riordan, Stephen M P
author_sort O'Connell, Susan M
collection PubMed
description In infants, especially with novel previously undescribed mutations of the K(ATP) channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed.
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spelling pubmed-46146632015-10-27 The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation O'Connell, Susan M Proks, Peter Kramer, Holger Mattis, Katia K Sachse, Gregor Joyce, Caroline Houghton, Jayne A L Ellard, Sian Hattersley, Andrew T Ashcroft, Frances M O'Riordan, Stephen M P Clin Case Rep Case Reports In infants, especially with novel previously undescribed mutations of the K(ATP) channel causing neonatal diabetes, in vitro studies can be used to both predict the response to sulphonylurea treatment and support a second trial of glibenclamide at higher than standard doses if the expected response is not observed. John Wiley & Sons, Ltd 2015-10 2015-09-08 /pmc/articles/PMC4614663/ /pubmed/26509030 http://dx.doi.org/10.1002/ccr3.370 Text en © 2015 The Authors. Clinical Case Reports published by John Wiley & Sons Ltd. http://creativecommons.org/licenses/by-nc-nd/4.0/ This is an open access article under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.
spellingShingle Case Reports
O'Connell, Susan M
Proks, Peter
Kramer, Holger
Mattis, Katia K
Sachse, Gregor
Joyce, Caroline
Houghton, Jayne A L
Ellard, Sian
Hattersley, Andrew T
Ashcroft, Frances M
O'Riordan, Stephen M P
The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title_full The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title_fullStr The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title_full_unstemmed The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title_short The value of in vitro studies in a case of neonatal diabetes with a novel Kir6.2-W68G mutation
title_sort value of in vitro studies in a case of neonatal diabetes with a novel kir6.2-w68g mutation
topic Case Reports
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614663/
https://www.ncbi.nlm.nih.gov/pubmed/26509030
http://dx.doi.org/10.1002/ccr3.370
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