Cargando…

TORC2: a novel target for treating age-associated memory impairment

Memory decline is one of the greatest health threats of the twenty-first century. Because of the widespread increase in life expectancy, 20 percent of the global population will be over 60 in 2050 and the problems caused by age-related memory loss will be dramatically aggravated. However, the molecu...

Descripción completa

Detalles Bibliográficos
Autores principales:	Johnson, Jennifer L., Huang, Wei, Roman, Gregg, Costa-Mattioli, Mauro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group 2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614817/ https://www.ncbi.nlm.nih.gov/pubmed/26489398 http://dx.doi.org/10.1038/srep15193

Ejemplares similares

mTORC2 controls actin polymerization required for consolidation of long-term memory
por: Huang, Wei, et al.
Publicado: (2013)

Regulation of filial imprinting and structural plasticity by mTORC1 in newborn chickens
por: Batista, Gervasio, et al.
Publicado: (2018)

mTORC2, but not mTORC1, is required for hippocampal mGluR-LTD and associated behaviors
por: Zhu, Ping Jun, et al.
Publicado: (2018)

Targeted suppression of mTORC2 reduces seizures across models of epilepsy
por: Okoh, James, et al.
Publicado: (2023)

Intrahippocampal glutamine administration inhibits mTORC1 signaling and impairs long-term memory
por: Rozas, Natalia S., et al.
Publicado: (2015)

Therapeutic inhibition of mTORC2 rescues the behavioral and neurophysiological abnormalities associated with Pten-deficiency.
por: Chen, Chien-Ju, et al.
Publicado: (2019)

mTORC1 controls long-term memory retrieval
por: Pereyra, Magdalena, et al.
Publicado: (2018)

Perspectives of Targeting mTORC1–S6K1 in Cardiovascular Aging
por: Ming, Xiu-Fen, et al.
Publicado: (2012)

Aging impairs contraction-induced human skeletal muscle mTORC1 signaling and protein synthesis
por: Fry, Christopher S, et al.
Publicado: (2011)

Disruption of Alcohol-Related Memories by mTORC1 Inhibition Prevents Relapse
por: Barak, Segev, et al.
Publicado: (2013)

Inhibition of mTORC2/RICTOR Impairs Melanoma Hepatic Metastasis()()
por: Schmidt, Katharina M., et al.
Publicado: (2018)

Lupus-associated atypical memory B cells are mTORC1-hyperactivated and functionally dysregulated
por: Wu, Chunmei, et al.
Publicado: (2019)

mTORC2 takes the longevity stAGE
por: Lamming, Dudley W.
Publicado: (2014)

Amino acid metabolites, mTORC1 and aging
por: Antikainen, Henri, et al.
Publicado: (2017)

Spearmint Extract Improves Working Memory in Men and Women with Age-Associated Memory Impairment
por: Herrlinger, Kelli A., et al.
Publicado: (2018)

Memory for sequences of events impaired in typical aging
por: Allen, Timothy A., et al.
Publicado: (2015)

TORC1-Dependent Phosphorylation Targets in Fission Yeast
por: Otsubo, Yoko, et al.
Publicado: (2017)

Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
por: Feldman, Morris E, et al.
Publicado: (2009)

Regulation of Autophagy through TORC1 and mTORC1
por: Noda, Takeshi
Publicado: (2017)

Novel Uracil-Based Inhibitors of Acetylcholinesterase with Potency for Treating Memory Impairment in an Animal Model of Alzheimer’s Disease
por: Semenov, Vyacheslav E., et al.
Publicado: (2022)

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases
por: Cadena Sandoval, Marti, et al.
Publicado: (2021)

Preserved memory-based orienting of attention with impaired explicit memory in healthy ageing
por: Salvato, Gerardo, et al.
Publicado: (2016)

Both mTORC1 and mTORC2 are involved in the regulation of cell adhesion
por: Chen, Long, et al.
Publicado: (2015)

Microglia and amyloid precursor protein coordinate control of transient Candida cerebritis with memory deficits
por: Wu, Yifan, et al.
Publicado: (2019)

Targeting folliculin to selectively inhibit mTORC1: a promising strategy for treating nonalcoholic fatty liver disease
por: Ling, Yan, et al.
Publicado: (2022)

KCNQ Channels Regulate Age-Related Memory Impairment
por: Cavaliere, Sonia, et al.
Publicado: (2013)

Administration of Glucosylceramide Ameliorated the Memory Impairment in Aged Mice
por: Lee, Yeonju, et al.
Publicado: (2013)

Sleep-dependent prospective memory consolidation is impaired with aging
por: Leong, Ruth L F, et al.
Publicado: (2021)

mTORC1 and mTORC2 in cancer and the tumor microenvironment
por: Kim, Laura C., et al.
Publicado: (2016)

Memory impairment in aged primates is associated with region-specific network dysfunction
por: Thomé, Alexander, et al.
Publicado: (2015)

Serotonin receptor HTR6-mediated mTORC1 signaling regulates dietary restriction–induced memory enhancement
por: Teng, Ling-Ling, et al.
Publicado: (2019)

Kynurenic acid accumulation underlies learning and memory impairment associated with aging
por: Vohra, Mihir, et al.
Publicado: (2018)

Loss of mTORC1 signalling impairs β-cell homeostasis and insulin processing
por: Blandino-Rosano, Manuel, et al.
Publicado: (2017)

ICAM5 as a Novel Target for Treating Cognitive Impairment in Fragile X Syndrome
por: Pei, Ya-ping, et al.
Publicado: (2020)

Dual inhibition of the mTORC1 and mTORC2 signaling pathways is a promising therapeutic target for adult T‐cell leukemia
por: Kawata, Takahito, et al.
Publicado: (2017)

The TORC1 inhibitor Nprl2 protects age-related digestive function in Drosophila
por: Xi, Junmeng, et al.
Publicado: (2019)

The hammer of TORC1!
por: Dufour, Eric
Publicado: (2015)

mTORC Inhibitors as Broad-Spectrum Therapeutics for Age-Related Diseases
por: Walters, Hannah E., et al.
Publicado: (2018)

TORC1 Organised in Inhibited Domains (TOROIDs) regulate TORC1 activity
por: Prouteau, Manoël, et al.
Publicado: (2017)

Pathogenic Role of mTORC1 and mTORC2 in Pulmonary Hypertension
por: Tang, Haiyang, et al.
Publicado: (2018)

Cannot write session to /tmp/vufind_sessions/sess_3mr96qoqsbsdvld3dm5bi20kft