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ATM regulates cell fate choice upon p53 activation by modulating mitochondrial turnover and ROS levels

Despite extensive study, the mechanisms of cell fate choice upon p53 activation remain poorly understood. Using genome-wide shRNA screening, we recently identified the ATM kinase as synthetic lethal with Nutlin-3, an MDM2 inhibitor that leads to non-genotoxic p53 activation. Here, we demonstrate tha...

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Detalles Bibliográficos
Autores principales:	Sullivan, Kelly D, Palaniappan, Vignesh V, Espinosa, Joaquín M
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Taylor & Francis 2014
Materias:	Reports
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4614823/ https://www.ncbi.nlm.nih.gov/pubmed/25483068 http://dx.doi.org/10.4161/15384101.2014.973330

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