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Virus-host arms race at the joint origin of multicellularity and programmed cell death
Unicellular eukaryotes and most prokaryotes possess distinct mechanisms of programmed cell death (PCD). How an “altruistic” trait, such as PCD, could evolve in unicellular organisms? To address this question, we developed a mathematical model of the virus-host co-evolution that involves interaction...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615056/ https://www.ncbi.nlm.nih.gov/pubmed/25486567 http://dx.doi.org/10.4161/15384101.2014.949496 |
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author | Iranzo, Jaime Lobkovsky, Alexander E Wolf, Yuri I Koonin, Eugene V |
author_facet | Iranzo, Jaime Lobkovsky, Alexander E Wolf, Yuri I Koonin, Eugene V |
author_sort | Iranzo, Jaime |
collection | PubMed |
description | Unicellular eukaryotes and most prokaryotes possess distinct mechanisms of programmed cell death (PCD). How an “altruistic” trait, such as PCD, could evolve in unicellular organisms? To address this question, we developed a mathematical model of the virus-host co-evolution that involves interaction between immunity, PCD and cellular aggregation. Analysis of the parameter space of this model shows that under high virus load and imperfect immunity, joint evolution of cell aggregation and PCD is the optimal evolutionary strategy. Given the abundance of viruses in diverse habitats and the wide spread of PCD in most organisms, these findings imply that multiple instances of the emergence of multicellularity and its essential attribute, PCD, could have been driven, at least in part, by the virus-host arms race. |
format | Online Article Text |
id | pubmed-4615056 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-46150562015-10-30 Virus-host arms race at the joint origin of multicellularity and programmed cell death Iranzo, Jaime Lobkovsky, Alexander E Wolf, Yuri I Koonin, Eugene V Cell Cycle Reports Unicellular eukaryotes and most prokaryotes possess distinct mechanisms of programmed cell death (PCD). How an “altruistic” trait, such as PCD, could evolve in unicellular organisms? To address this question, we developed a mathematical model of the virus-host co-evolution that involves interaction between immunity, PCD and cellular aggregation. Analysis of the parameter space of this model shows that under high virus load and imperfect immunity, joint evolution of cell aggregation and PCD is the optimal evolutionary strategy. Given the abundance of viruses in diverse habitats and the wide spread of PCD in most organisms, these findings imply that multiple instances of the emergence of multicellularity and its essential attribute, PCD, could have been driven, at least in part, by the virus-host arms race. Taylor & Francis 2014-10-30 /pmc/articles/PMC4615056/ /pubmed/25486567 http://dx.doi.org/10.4161/15384101.2014.949496 Text en This article not subject to US copyright law. http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Reports Iranzo, Jaime Lobkovsky, Alexander E Wolf, Yuri I Koonin, Eugene V Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title | Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title_full | Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title_fullStr | Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title_full_unstemmed | Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title_short | Virus-host arms race at the joint origin of multicellularity and programmed cell death |
title_sort | virus-host arms race at the joint origin of multicellularity and programmed cell death |
topic | Reports |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615056/ https://www.ncbi.nlm.nih.gov/pubmed/25486567 http://dx.doi.org/10.4161/15384101.2014.949496 |
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