Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact

Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific...

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Detalles Bibliográficos
Autores principales: Grade, Marian, Becker, Heinz, Liersch, Torsten, Ried, Thomas, Ghadimi, B. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615150/
https://www.ncbi.nlm.nih.gov/pubmed/16823176
http://dx.doi.org/10.1155/2006/173815
Descripción
Sumario:Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.

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