Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact

Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific...

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Detalles Bibliográficos
Autores principales: Grade, Marian, Becker, Heinz, Liersch, Torsten, Ried, Thomas, Ghadimi, B. Michael
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2006
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615150/
https://www.ncbi.nlm.nih.gov/pubmed/16823176
http://dx.doi.org/10.1155/2006/173815
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author Grade, Marian
Becker, Heinz
Liersch, Torsten
Ried, Thomas
Ghadimi, B. Michael
author_facet Grade, Marian
Becker, Heinz
Liersch, Torsten
Ried, Thomas
Ghadimi, B. Michael
author_sort Grade, Marian
collection PubMed
description Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact.
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spelling pubmed-46151502016-01-12 Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact Grade, Marian Becker, Heinz Liersch, Torsten Ried, Thomas Ghadimi, B. Michael Cell Oncol Review Chromosomal aberrations play a dominant role in colorectal carcinogenesis. The application of fluorescence in situ hybridization (FISH) based techniques such as comparative genomic hybridization (CGH) and spectral karyotyping (SKY) revealed that colorectal carcinomas are characterized by a specific pattern of chromosomal imbalances which sequentially accumulate during cancer progression. This review aims to summarize molecular cytogenetic studies, provides a background on the functional relevance of chromosomal aberrations for colorectal cancer progression and discusses their potential clinical impact. IOS Press 2006 2006-07-05 /pmc/articles/PMC4615150/ /pubmed/16823176 http://dx.doi.org/10.1155/2006/173815 Text en Copyright © 2006 Hindawi Publishing Corporation and the authors.
spellingShingle Review
Grade, Marian
Becker, Heinz
Liersch, Torsten
Ried, Thomas
Ghadimi, B. Michael
Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title_full Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title_fullStr Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title_full_unstemmed Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title_short Molecular Cytogenetics: Genomic Imbalances in Colorectal Cancer and their Clinical Impact
title_sort molecular cytogenetics: genomic imbalances in colorectal cancer and their clinical impact
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615150/
https://www.ncbi.nlm.nih.gov/pubmed/16823176
http://dx.doi.org/10.1155/2006/173815
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