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Detection of Tumor Cells in Bone Marrow, Peripheral Blood and Lymph Nodes by Automated Imaging Devices

The presence of tumor cells in bone marrow, peripheral blood and lymph nodes has proven its clinical and prognostic value. Since the frequency of these cells in bone marrow and blood is sometimes as low as 1 per million and due to the fact that for the analysis of lymph nodes many sectioning levels...

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Detalles Bibliográficos
Autores principales: Mesker, Wilma E., Vrolijk, Hans, Sloos, Willem C. R., Tollenaar, Rob A. E. M., Tanke, Hans J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: IOS Press 2006
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615155/
https://www.ncbi.nlm.nih.gov/pubmed/16988469
http://dx.doi.org/10.1155/2006/610562
Descripción
Sumario:The presence of tumor cells in bone marrow, peripheral blood and lymph nodes has proven its clinical and prognostic value. Since the frequency of these cells in bone marrow and blood is sometimes as low as 1 per million and due to the fact that for the analysis of lymph nodes many sectioning levels have to be analyzed, automated imaging devices have been suggested as an useful alternative to conventional manual screening of specimens. The aim of this paper is to review the performance of current equipment that is commercially available, based on literature published so far. Requirements for introducing this equipment for routine clinical practice are discussed.