Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors

Non-small cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting tumor suppressor loss. Smad4 is an established tumor suppressor in pancreatic and colon cancer, however, the consequences of Smad4 loss in l...

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Detalles Bibliográficos
Autores principales: Haeger, Sarah M., Thompson, Joshua J., Kalra, Sean, Cleaver, Timothy G., Merrick, Daniel, Wang, Xiao-Jing, Malkoski, Stephen P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2015
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615192/
https://www.ncbi.nlm.nih.gov/pubmed/25893305
http://dx.doi.org/10.1038/onc.2015.112

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615192/
https://www.ncbi.nlm.nih.gov/pubmed/25893305
http://dx.doi.org/10.1038/onc.2015.112

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