Cargando…

Smad4 loss promotes lung cancer formation but increases sensitivity to DNA topoisomerase inhibitors

Non-small cell lung cancer (NSCLC) is a common malignancy with a poor prognosis. Despite progress targeting oncogenic drivers, there are no therapies targeting tumor suppressor loss. Smad4 is an established tumor suppressor in pancreatic and colon cancer, however, the consequences of Smad4 loss in l...

Descripción completa

Detalles Bibliográficos
Autores principales:	Haeger, Sarah M., Thompson, Joshua J., Kalra, Sean, Cleaver, Timothy G., Merrick, Daniel, Wang, Xiao-Jing, Malkoski, Stephen P.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2015
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615192/ https://www.ncbi.nlm.nih.gov/pubmed/25893305 http://dx.doi.org/10.1038/onc.2015.112

Ejemplares similares

Developments in Non-Intercalating Bacterial Topoisomerase Inhibitors: Allosteric and ATPase Inhibitors of DNA Gyrase and Topoisomerase IV
por: Grossman, Scott, et al.
Publicado: (2023)

Topoisomerase Inhibitors Increase Episomal DNA Expression by Inducing the Integration of Episomal DNA in Hepatic Cells
por: Gómez-Moreno, Andoni, et al.
Publicado: (2023)

CK2-Mediated Hyperphosphorylation of Topoisomerase I Targets Serine 506, Enhances Topoisomerase I–DNA Binding, and Increases Cellular Camptothecin Sensitivity
por: Bandyopadhyay, Keya, et al.
Publicado: (2012)

Small DNA circles as bacterial topoisomerase I inhibitors
por: Li, Dawei, et al.
Publicado: (2019)

DNA Topoisomerase Inhibitors: Trapping a DNA-Cleaving Machine in Motion
por: Bax, Benjamin D., et al.
Publicado: (2019)

Mitotic chromosomes are constrained by topoisomerase II–sensitive DNA entanglements
por: Kawamura, Ryo, et al.
Publicado: (2010)

Keratin promoter based gene manipulation in the murine conducting airway
por: Malkoski, Stephen P., et al.
Publicado: (2010)

Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines.
por: Houlbrook, S., et al.
Publicado: (1995)

Relationship between expression of topoisomerase II isoforms and intrinsic sensitivity to topoisomerase II inhibitors in breast cancer cell lines
Publicado: (1996)

Etoposide promotes DNA loop trapping and barrier formation by topoisomerase II
por: Le, Tung T., et al.
Publicado: (2023)

An RNase-sensitive particle containing Drosophila melanogaster DNA topoisomerase II
Publicado: (1994)

p16(INK4) Expression Is Associated with the Increased Sensitivity of Human Non‐small Cell Lung Cancer Cells to DNA Topoisomerase I Inhibitors
por: Fukuoka, Kazuya, et al.
Publicado: (1997)

CD26/dipeptidyl peptidase IV enhances expression of topoisomerase II alpha and sensitivity to apoptosis induced by topoisomerase II inhibitors
por: Sato, K, et al.
Publicado: (2003)

Potentiation of Topoisomerase I and II Inhibitors Cell Killing by Tumor Necrosis Factor: Relationship to DNA Strand Breakage Formation
por: Orengo, Giorgia, et al.
Publicado: (1992)

Inhibition of FGFR2-Signaling Attenuates a Homology-Mediated DNA Repair in GIST and Sensitizes Them to DNA-Topoisomerase II Inhibitors
por: Sergei, Boichuk, et al.
Publicado: (2020)

Functions of the CSB Protein at Topoisomerase 2 Inhibitors-Induced DNA Lesions
por: Busatto, Franciele Faccio, et al.
Publicado: (2021)

Pim kinase inhibition sensitizes FLT3-ITD acute myeloid leukemia cells to topoisomerase 2 inhibitors through increased DNA damage and oxidative stress
por: Doshi, Kshama A., et al.
Publicado: (2016)

Formation and repair of psoralen-DNA adducts and pyrimidine dimers in human DNA and chromatin.
por: Cleaver, J E, et al.
Publicado: (1985)

DNA-Topology Simplification by Topoisomerases
por: Hanke, Andreas, et al.
Publicado: (2021)

The Structural Features of Novel Bacterial Topoisomerase Inhibitors That Define Their Activity on Topoisomerase IV
por: Kokot, Maja, et al.
Publicado: (2022)

Inhibition of Hsp90 acts synergistically with topoisomerase II poisons to increase the apoptotic killing of cells due to an increase in topoisomerase II mediated DNA damage
por: Barker, Catherine R., et al.
Publicado: (2006)

Actions of a Novel Bacterial Topoisomerase Inhibitor against Neisseria gonorrhoeae Gyrase and Topoisomerase IV: Enhancement of Double-Stranded DNA Breaks
por: Dauda, Soziema E., et al.
Publicado: (2023)

Expanding the type IIB DNA topoisomerase family: identification of new topoisomerase and topoisomerase-like proteins in mobile genetic elements
por: Takahashi, Diane T, et al.
Publicado: (2019)

SULF2 Methylation is Prognostic for Lung Cancer Survival and Increases Sensitivity to Topoisomerase-I inhibitors via Induction of ISG15
por: Tessema, Mathewos, et al.
Publicado: (2011)

DNA topoisomerase inhibition with the HIF inhibitor acriflavine promotes transcription of lncRNAs in endothelial cells
por: Seredinski, Sandra, et al.
Publicado: (2022)

Antibacterial activity of novel dual bacterial DNA type II topoisomerase inhibitors
por: D’Atanasio, Noemi, et al.
Publicado: (2020)

Hyperthermia, thermotolerance and topoisomerase II inhibitors.
por: Kampinga, H. H.
Publicado: (1995)

The Effect of Topoisomerase I Inhibitors on the Efficacy of T-Cell-Based Cancer Immunotherapy
por: McKenzie, Jodi A, et al.
Publicado: (2017)

The modulation of topoisomerase I-mediated DNA cleavage and the induction of DNA–topoisomerase I crosslinks by crotonaldehyde-derived DNA adducts
por: Dexheimer, Thomas S., et al.
Publicado: (2008)

Correction to ‘Expanding the type IIB DNA topoisomerase family: identification of new topoisomerase and topoisomerase-like proteins in mobile genetic elements’
Publicado: (2022)

Targeting DNA topoisomerases: past & future
por: Gmeiner, William H., et al.
Publicado: (2021)

Bacterial topoisomerase I and topoisomerase III relax supercoiled DNA via distinct pathways
por: Terekhova, Ksenia, et al.
Publicado: (2012)

Evodiamine Stabilizes Topoisomerase I-DNA Cleavable Complex to Inhibit Topoisomerase I Activity
por: Chan, Agnes L.-F., et al.
Publicado: (2009)

Sensitization of Cancer Cells to Radiation and Topoisomerase I Inhibitor Camptothecin Using Inhibitors of PARP and Other Signaling Molecules
por: Matsuno, Yusuke, et al.
Publicado: (2018)

Inhibition of archaeal growth and DNA topoisomerase VI activities by the Hsp90 inhibitor radicicol
por: Gadelle, D., et al.
Publicado: (2005)

Antibacterial activity of a DNA topoisomerase I inhibitor versus fluoroquinolones in Streptococcus pneumoniae
por: Valenzuela, Myriam V., et al.
Publicado: (2020)

Substituted 4,5′-Bithiazoles as Catalytic Inhibitors of Human DNA Topoisomerase IIα
por: Bergant Loboda, Kaja, et al.
Publicado: (2020)

The Deubiquitinating Enzyme Inhibitor PR-619 is a Potent DNA Topoisomerase II Poison
por: Cowell, Ian G., et al.
Publicado: (2019)

Mechanisms regulating resistance to inhibitors of topoisomerase II
por: Ganapathi, Ram N., et al.
Publicado: (2013)

Dual Inhibitors Against Topoisomerases and Histone Deacetylases
por: Seo, Young Ho
Publicado: (2015)

Cannot write session to /tmp/vufind_sessions/sess_1nj3oajh9h9q0advjblb05ve1e