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Nonmuscle Tissues Contribution to Cancer Cachexia
Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi Publishing Corporation
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615210/ https://www.ncbi.nlm.nih.gov/pubmed/26523094 http://dx.doi.org/10.1155/2015/182872 |
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author | Argilés, Josep M. Stemmler, Britta López-Soriano, Francisco J. Busquets, Silvia |
author_facet | Argilés, Josep M. Stemmler, Britta López-Soriano, Francisco J. Busquets, Silvia |
author_sort | Argilés, Josep M. |
collection | PubMed |
description | Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the wasting that occurs during cachexia, recent developments suggest that tissues/organs such as adipose (both brown and white), brain, liver, gut, and heart are directly involved in the cachectic process and may be responsible for muscle wasting. This suggests that cachexia is indeed a multiorgan syndrome. Bearing all this in mind, the aim of the present review is to examine the impact of nonmuscle tissues in cancer cachexia. |
format | Online Article Text |
id | pubmed-4615210 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Hindawi Publishing Corporation |
record_format | MEDLINE/PubMed |
spelling | pubmed-46152102015-11-01 Nonmuscle Tissues Contribution to Cancer Cachexia Argilés, Josep M. Stemmler, Britta López-Soriano, Francisco J. Busquets, Silvia Mediators Inflamm Review Article Cachexia is a syndrome associated with cancer, characterized by body weight loss, muscle and adipose tissue wasting, and inflammation, being often associated with anorexia. In spite of the fact that muscle tissue represents more than 40% of body weight and seems to be the main tissue involved in the wasting that occurs during cachexia, recent developments suggest that tissues/organs such as adipose (both brown and white), brain, liver, gut, and heart are directly involved in the cachectic process and may be responsible for muscle wasting. This suggests that cachexia is indeed a multiorgan syndrome. Bearing all this in mind, the aim of the present review is to examine the impact of nonmuscle tissues in cancer cachexia. Hindawi Publishing Corporation 2015 2015-10-07 /pmc/articles/PMC4615210/ /pubmed/26523094 http://dx.doi.org/10.1155/2015/182872 Text en Copyright © 2015 Josep M. Argilés et al. https://creativecommons.org/licenses/by/3.0/ This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Review Article Argilés, Josep M. Stemmler, Britta López-Soriano, Francisco J. Busquets, Silvia Nonmuscle Tissues Contribution to Cancer Cachexia |
title | Nonmuscle Tissues Contribution to Cancer Cachexia |
title_full | Nonmuscle Tissues Contribution to Cancer Cachexia |
title_fullStr | Nonmuscle Tissues Contribution to Cancer Cachexia |
title_full_unstemmed | Nonmuscle Tissues Contribution to Cancer Cachexia |
title_short | Nonmuscle Tissues Contribution to Cancer Cachexia |
title_sort | nonmuscle tissues contribution to cancer cachexia |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615210/ https://www.ncbi.nlm.nih.gov/pubmed/26523094 http://dx.doi.org/10.1155/2015/182872 |
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