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The role of MicroRNAs in Osteoclasts and Osteoporosis

Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusi...

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Detalles Bibliográficos
Autores principales: Tang, Peifu, Xiong, Qi, Ge, Wei, Zhang, Lihai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Taylor & Francis 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615571/
https://www.ncbi.nlm.nih.gov/pubmed/25692234
http://dx.doi.org/10.1080/15476286.2014.996462
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author Tang, Peifu
Xiong, Qi
Ge, Wei
Zhang, Lihai
author_facet Tang, Peifu
Xiong, Qi
Ge, Wei
Zhang, Lihai
author_sort Tang, Peifu
collection PubMed
description Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis.
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spelling pubmed-46155712016-02-03 The role of MicroRNAs in Osteoclasts and Osteoporosis Tang, Peifu Xiong, Qi Ge, Wei Zhang, Lihai RNA Biol Review Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis. Taylor & Francis 2015-02-18 /pmc/articles/PMC4615571/ /pubmed/25692234 http://dx.doi.org/10.1080/15476286.2014.996462 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted.
spellingShingle Review
Tang, Peifu
Xiong, Qi
Ge, Wei
Zhang, Lihai
The role of MicroRNAs in Osteoclasts and Osteoporosis
title The role of MicroRNAs in Osteoclasts and Osteoporosis
title_full The role of MicroRNAs in Osteoclasts and Osteoporosis
title_fullStr The role of MicroRNAs in Osteoclasts and Osteoporosis
title_full_unstemmed The role of MicroRNAs in Osteoclasts and Osteoporosis
title_short The role of MicroRNAs in Osteoclasts and Osteoporosis
title_sort role of micrornas in osteoclasts and osteoporosis
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615571/
https://www.ncbi.nlm.nih.gov/pubmed/25692234
http://dx.doi.org/10.1080/15476286.2014.996462
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