Cargando…
The role of MicroRNAs in Osteoclasts and Osteoporosis
Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusi...
Autores principales: | , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Taylor & Francis
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615571/ https://www.ncbi.nlm.nih.gov/pubmed/25692234 http://dx.doi.org/10.1080/15476286.2014.996462 |
_version_ | 1782396495073378304 |
---|---|
author | Tang, Peifu Xiong, Qi Ge, Wei Zhang, Lihai |
author_facet | Tang, Peifu Xiong, Qi Ge, Wei Zhang, Lihai |
author_sort | Tang, Peifu |
collection | PubMed |
description | Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis. |
format | Online Article Text |
id | pubmed-4615571 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Taylor & Francis |
record_format | MEDLINE/PubMed |
spelling | pubmed-46155712016-02-03 The role of MicroRNAs in Osteoclasts and Osteoporosis Tang, Peifu Xiong, Qi Ge, Wei Zhang, Lihai RNA Biol Review Osteoclasts are the exclusive cells of bone resorption. Abnormally activating osteoclasts can lead to low bone mineral density, which will cause osteopenia, osteoporosis, and other bone disorders. To date, the mechanism of how osteoclast precursors differentiate into mature osteoclasts remains elusive. MicroRNAs (miRNAs) are novel regulatory factors that play an important role in numerous cellular processes, including cell differentiation and apoptosis, by post-transcriptional regulation of genes. Recently, a number of studies have revealed that miRNAs participate in bone homeostasis, including osteoclastic bone resorption, which sheds light on the mechanisms underlying osteoclast differentiation. In this review, we highlight the miRNAs involved in regulating osteoclast differentiation and bone resorption, and their roles in osteoporosis. Taylor & Francis 2015-02-18 /pmc/articles/PMC4615571/ /pubmed/25692234 http://dx.doi.org/10.1080/15476286.2014.996462 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
spellingShingle | Review Tang, Peifu Xiong, Qi Ge, Wei Zhang, Lihai The role of MicroRNAs in Osteoclasts and Osteoporosis |
title | The role of MicroRNAs in Osteoclasts and Osteoporosis |
title_full | The role of MicroRNAs in Osteoclasts and Osteoporosis |
title_fullStr | The role of MicroRNAs in Osteoclasts and Osteoporosis |
title_full_unstemmed | The role of MicroRNAs in Osteoclasts and Osteoporosis |
title_short | The role of MicroRNAs in Osteoclasts and Osteoporosis |
title_sort | role of micrornas in osteoclasts and osteoporosis |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615571/ https://www.ncbi.nlm.nih.gov/pubmed/25692234 http://dx.doi.org/10.1080/15476286.2014.996462 |
work_keys_str_mv | AT tangpeifu theroleofmicrornasinosteoclastsandosteoporosis AT xiongqi theroleofmicrornasinosteoclastsandosteoporosis AT gewei theroleofmicrornasinosteoclastsandosteoporosis AT zhanglihai theroleofmicrornasinosteoclastsandosteoporosis AT tangpeifu roleofmicrornasinosteoclastsandosteoporosis AT xiongqi roleofmicrornasinosteoclastsandosteoporosis AT gewei roleofmicrornasinosteoclastsandosteoporosis AT zhanglihai roleofmicrornasinosteoclastsandosteoporosis |