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Local RNA flexibility perturbation of the IRES element induced by a novel ligand inhibits viral RNA translation
The internal ribosome entry site (IRES) element located at the 5´untranslated genomic region of various RNA viruses mediates cap-independent initiation of translation. Picornavirus IRES activity is highly dependent on both its structural organization and its interaction with host factors. Small mole...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Taylor & Francis
2015
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615676/ https://www.ncbi.nlm.nih.gov/pubmed/25775053 http://dx.doi.org/10.1080/15476286.2015.1025190 |