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mRNA localization in the Drosophila germline
Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This review will discuss the diverse roles of mRNA...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Taylor & Francis
2014
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615827/ https://www.ncbi.nlm.nih.gov/pubmed/25482896 http://dx.doi.org/10.4161/rna.36097 |
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| author | Weil, Timothy T |
| author_facet | Weil, Timothy T |
| author_sort | Weil, Timothy T |
| collection | PubMed |
| description | Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This review will discuss the diverse roles of mRNA localization in the Drosophila germline, the cis-elements and cellular components regulating localization and the superimposition of translational regulatory mechanisms. Despite a history of discovery, there are still many fundamental questions regarding mRNA localization that remain unanswered. Take home messages, outstanding questions and future approaches that will likely lead to resolving these unknowns in the future are summarized at the end. |
| format | Online Article Text |
| id | pubmed-4615827 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2014 |
| publisher | Taylor & Francis |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-46158272015-10-31 mRNA localization in the Drosophila germline Weil, Timothy T RNA Biol Review Localization and the associated translational control of mRNA is a well established mechanism for segregating cellular protein expression. Drosophila has been instrumental in deciphering the prevailing mechanisms of mRNA localization and regulation. This review will discuss the diverse roles of mRNA localization in the Drosophila germline, the cis-elements and cellular components regulating localization and the superimposition of translational regulatory mechanisms. Despite a history of discovery, there are still many fundamental questions regarding mRNA localization that remain unanswered. Take home messages, outstanding questions and future approaches that will likely lead to resolving these unknowns in the future are summarized at the end. Taylor & Francis 2014-10-31 /pmc/articles/PMC4615827/ /pubmed/25482896 http://dx.doi.org/10.4161/rna.36097 Text en © 2014 The Author(s). Published with license by Taylor & Francis Group, LLC http://creativecommons.org/licenses/by-nc/3.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution-Non-Commercial License (http://creativecommons.org/licenses/by-nc/3.0/), which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited. The moral rights of the named author(s) have been asserted. |
| spellingShingle | Review Weil, Timothy T mRNA localization in the Drosophila germline |
| title | mRNA localization in the Drosophila germline |
| title_full | mRNA localization in the Drosophila germline |
| title_fullStr | mRNA localization in the Drosophila germline |
| title_full_unstemmed | mRNA localization in the Drosophila germline |
| title_short | mRNA localization in the Drosophila germline |
| title_sort | mrna localization in the drosophila germline |
| topic | Review |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615827/ https://www.ncbi.nlm.nih.gov/pubmed/25482896 http://dx.doi.org/10.4161/rna.36097 |
| work_keys_str_mv | AT weiltimothyt mrnalocalizationinthedrosophilagermline |