New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China

New reassortant H5N8 highly pathogenic avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/w...

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Autores principales: Song, Yafen, Cui, Jin, Song, Hui, Ye, Jiaqi, Zhao, Zhishan, Wu, Siyu, Xu, Chenggang, Jiao, Peirong, Liao, Ming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2015
Materias:
Microbiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615950/
https://www.ncbi.nlm.nih.gov/pubmed/26557113
http://dx.doi.org/10.3389/fmicb.2015.01170
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author Song, Yafen
Cui, Jin
Song, Hui
Ye, Jiaqi
Zhao, Zhishan
Wu, Siyu
Xu, Chenggang
Jiao, Peirong
Liao, Ming
author_facet Song, Yafen
Cui, Jin
Song, Hui
Ye, Jiaqi
Zhao, Zhishan
Wu, Siyu
Xu, Chenggang
Jiao, Peirong
Liao, Ming
author_sort Song, Yafen
collection PubMed
description New reassortant H5N8 highly pathogenic avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/wild duck/Shandong/1/2011 (H5N1) and A/duck/Jiangsu/k1203/2010 (H5N8). However, the HA, NA, PB1, PA, M, and NS genes had the highest identity with A/duck/Jiangsu/k1203/2010 (H5N8). Phylogenetic analysis revealed that their HA genes belonged to the same GsGd H5 clade 2.3.4.4 detected in China in 2010. Therefore, we supposed that these H5N8 viruses might be novel reassortant viruses that have a H5N8 backbone while acquiring PB2 and NP genes from H5N1 viruses. This study is useful for better understanding the genetic and antigenic evolution of H5 avian influenza viruses in Southern China.
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spelling pubmed-46159502015-11-09 New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China Song, Yafen Cui, Jin Song, Hui Ye, Jiaqi Zhao, Zhishan Wu, Siyu Xu, Chenggang Jiao, Peirong Liao, Ming Front Microbiol Microbiology New reassortant H5N8 highly pathogenic avian influenza viruses were isolated from waterfowl in Southern China. Blast analysis demonstrated that the PB2 gene in these viruses were most closely related to A/wild duck/Shangdong/628/2011 (H5N1), while their NP genes were both more closely related to A/wild duck/Shandong/1/2011 (H5N1) and A/duck/Jiangsu/k1203/2010 (H5N8). However, the HA, NA, PB1, PA, M, and NS genes had the highest identity with A/duck/Jiangsu/k1203/2010 (H5N8). Phylogenetic analysis revealed that their HA genes belonged to the same GsGd H5 clade 2.3.4.4 detected in China in 2010. Therefore, we supposed that these H5N8 viruses might be novel reassortant viruses that have a H5N8 backbone while acquiring PB2 and NP genes from H5N1 viruses. This study is useful for better understanding the genetic and antigenic evolution of H5 avian influenza viruses in Southern China. Frontiers Media S.A. 2015-10-23 /pmc/articles/PMC4615950/ /pubmed/26557113 http://dx.doi.org/10.3389/fmicb.2015.01170 Text en Copyright © 2015 Song, Cui, Song, Ye, Zhao, Wu, Xu, Jiao and Liao. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Song, Yafen
Cui, Jin
Song, Hui
Ye, Jiaqi
Zhao, Zhishan
Wu, Siyu
Xu, Chenggang
Jiao, Peirong
Liao, Ming
New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title_full New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title_fullStr New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title_full_unstemmed New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title_short New reassortant H5N8 highly pathogenic avian influenza virus from waterfowl in Southern China
title_sort new reassortant h5n8 highly pathogenic avian influenza virus from waterfowl in southern china
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4615950/
https://www.ncbi.nlm.nih.gov/pubmed/26557113
http://dx.doi.org/10.3389/fmicb.2015.01170
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