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Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form
In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it i...
Autores principales: | , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616227/ https://www.ncbi.nlm.nih.gov/pubmed/26494465 http://dx.doi.org/10.1038/srep15685 |
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author | Seo, Hyo Jung Nam, Sang Hwan Im, Hyung-Jun Park, Ji-yong Lee, Ji Youn Yoo, Byeongjun Lee, Yun-Sang Jeong, Jae Min Hyeon, Taeghwan Who Kim, Ji Lee, Jae Sung Jang, In-Jin Cho, Joo-Youn Hwang, Do Won Suh, Yung Doug Lee, Dong Soo |
author_facet | Seo, Hyo Jung Nam, Sang Hwan Im, Hyung-Jun Park, Ji-yong Lee, Ji Youn Yoo, Byeongjun Lee, Yun-Sang Jeong, Jae Min Hyeon, Taeghwan Who Kim, Ji Lee, Jae Sung Jang, In-Jin Cho, Joo-Youn Hwang, Do Won Suh, Yung Doug Lee, Dong Soo |
author_sort | Seo, Hyo Jung |
collection | PubMed |
description | In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated (64)Cu-labeled upconverting nanoparticles (micelle encapsulated (64)Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated (64)Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of (64)Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property. |
format | Online Article Text |
id | pubmed-4616227 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Nature Publishing Group |
record_format | MEDLINE/PubMed |
spelling | pubmed-46162272015-10-29 Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form Seo, Hyo Jung Nam, Sang Hwan Im, Hyung-Jun Park, Ji-yong Lee, Ji Youn Yoo, Byeongjun Lee, Yun-Sang Jeong, Jae Min Hyeon, Taeghwan Who Kim, Ji Lee, Jae Sung Jang, In-Jin Cho, Joo-Youn Hwang, Do Won Suh, Yung Doug Lee, Dong Soo Sci Rep Article In the field of nanomedicine, long term accumulation of nanoparticles (NPs) in the mononuclear phagocyte system (MPS) such as liver is the major hurdle in clinical translation. On the other hand, NPs could be excreted via hepatobiliary excretion pathway without overt tissue toxicity. Therefore, it is critical to develop NPs that show favorable excretion property. Herein, we demonstrated that micelle encapsulated (64)Cu-labeled upconverting nanoparticles (micelle encapsulated (64)Cu-NOTA-UCNPs) showed substantial hepatobiliary excretion by in vivo positron emission tomography (PET) and also upconversion luminescence imaging (ULI). Ex vivo biodistribution study reinforced the imaging results by showing clearance of 84% of initial hepatic uptake in 72 hours. Hepatobiliary excretion of the UCNPs was also verified by transmission electron microscopy (TEM) examination. Micelle encapsulated (64)Cu-NOTA-UCNPs could be an optimal bimodal imaging agent owing to quantifiability of (64)Cu, ability of in vivo/ex vivo ULI and good hepatobiliary excretion property. Nature Publishing Group 2015-10-23 /pmc/articles/PMC4616227/ /pubmed/26494465 http://dx.doi.org/10.1038/srep15685 Text en Copyright © 2015, Macmillan Publishers Limited http://creativecommons.org/licenses/by/4.0/ This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ |
spellingShingle | Article Seo, Hyo Jung Nam, Sang Hwan Im, Hyung-Jun Park, Ji-yong Lee, Ji Youn Yoo, Byeongjun Lee, Yun-Sang Jeong, Jae Min Hyeon, Taeghwan Who Kim, Ji Lee, Jae Sung Jang, In-Jin Cho, Joo-Youn Hwang, Do Won Suh, Yung Doug Lee, Dong Soo Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title | Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title_full | Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title_fullStr | Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title_full_unstemmed | Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title_short | Rapid Hepatobiliary Excretion of Micelle-Encapsulated/Radiolabeled Upconverting Nanoparticles as an Integrated Form |
title_sort | rapid hepatobiliary excretion of micelle-encapsulated/radiolabeled upconverting nanoparticles as an integrated form |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616227/ https://www.ncbi.nlm.nih.gov/pubmed/26494465 http://dx.doi.org/10.1038/srep15685 |
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