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Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach
The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using (18)F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral o...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616321/ https://www.ncbi.nlm.nih.gov/pubmed/25340494 http://dx.doi.org/10.1097/MD.0000000000000103 |
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author | Micarelli, Alessandro Pagani, Marco Chiaravalloti, Agostino Bruno, Ernesto Pavone, Isabella Candidi, Matteo Danieli, Roberta Schillaci, Orazio Alessandrini, Marco |
author_facet | Micarelli, Alessandro Pagani, Marco Chiaravalloti, Agostino Bruno, Ernesto Pavone, Isabella Candidi, Matteo Danieli, Roberta Schillaci, Orazio Alessandrini, Marco |
author_sort | Micarelli, Alessandro |
collection | PubMed |
description | The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using (18)F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral olfactory condition (NC) and, after 1 month, to a pure olfactory condition (OC) in a relatively ecological environment, that is, outside the scanner. All the subjects were injected with 185–210 megabecquerel of (18)F FDG during both stimulations. Statistical parametric mapping version 2 was used in order to assess differences between NC and OC. As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere. During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex. The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided. |
format | Online Article Text |
id | pubmed-4616321 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46163212015-10-27 Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach Micarelli, Alessandro Pagani, Marco Chiaravalloti, Agostino Bruno, Ernesto Pavone, Isabella Candidi, Matteo Danieli, Roberta Schillaci, Orazio Alessandrini, Marco Medicine (Baltimore) 6800 The aim of this article is to investigate the cortical metabolic arrangements in olfactory processing by using (18)F fluorodeoxyglucose (FDG) positron emission tomography/computed tomography. Twenty-six normosmic individuals (14 women and 12 men; mean age 46.7 ± 10 years) were exposed to a neutral olfactory condition (NC) and, after 1 month, to a pure olfactory condition (OC) in a relatively ecological environment, that is, outside the scanner. All the subjects were injected with 185–210 megabecquerel of (18)F FDG during both stimulations. Statistical parametric mapping version 2 was used in order to assess differences between NC and OC. As a result, we found a significant higher glucose consumption during OC in the cuneus, lingual, and parahippocampal gyri, mainly in the left hemisphere. During NC, our results show a relative higher glucose metabolism in the left superior, inferior, middle, medial frontal, and orbital gyri as well as in the anterior cingulate cortex. The present investigation, performed with a widely available functional imaging clinical tool, may help to better understand the neural responses associated to olfactory processing in healthy individuals and in patients with olfactory disorders by acquiring data in an ecologic, noise-free, and resting condition in which possible cerebral activations related to unwanted attentional processes might be avoided. Wolters Kluwer Health 2014-10-17 /pmc/articles/PMC4616321/ /pubmed/25340494 http://dx.doi.org/10.1097/MD.0000000000000103 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 6800 Micarelli, Alessandro Pagani, Marco Chiaravalloti, Agostino Bruno, Ernesto Pavone, Isabella Candidi, Matteo Danieli, Roberta Schillaci, Orazio Alessandrini, Marco Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title | Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title_full | Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title_fullStr | Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title_full_unstemmed | Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title_short | Cortical Metabolic Arrangement During Olfactory Processing: Proposal for a (18)F FDG PET/CT Methodological Approach |
title_sort | cortical metabolic arrangement during olfactory processing: proposal for a (18)f fdg pet/ct methodological approach |
topic | 6800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616321/ https://www.ncbi.nlm.nih.gov/pubmed/25340494 http://dx.doi.org/10.1097/MD.0000000000000103 |
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