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Infliximab for Peripheral Ulcerative Keratitis Treatment
Biologic agents such as anti-TNFα have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2014
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616390/ https://www.ncbi.nlm.nih.gov/pubmed/25474432 http://dx.doi.org/10.1097/MD.0000000000000176 |
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author | Huerva, Valentín Ascaso, Francisco J. Grzybowski, Andrzej |
author_facet | Huerva, Valentín Ascaso, Francisco J. Grzybowski, Andrzej |
author_sort | Huerva, Valentín |
collection | PubMed |
description | Biologic agents such as anti-TNFα have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis. In many cases, the disease may be resistant to high doses of systemic corticosteroids and immunosuppressants. Chimeric anti-TNFα has been employed when all other treatments have failed. Isolated cases and short series of cases have been reported. This paper summarizes the available reports on the use, efficacy, and safety of infliximab in the treatment of PUK. |
format | Online Article Text |
id | pubmed-4616390 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2014 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46163902015-10-27 Infliximab for Peripheral Ulcerative Keratitis Treatment Huerva, Valentín Ascaso, Francisco J. Grzybowski, Andrzej Medicine (Baltimore) 5800 Biologic agents such as anti-TNFα have been employed in treatment paradigms for ocular inflammation. Peripheral corneal ulceration (PUK) is a devastating disorder consisting of a crescent-shaped area of destructive inflammation at the margin of the corneal stroma. It is associated with an epithelial defect, the presence of stromal inflammatory cells, and progressive stromal degradation and thinning, leading to ocular perforation and devastating visual loss. Macroulcerative PUK is usually a local manifestation of a systemic vasculitis. In many cases, the disease may be resistant to high doses of systemic corticosteroids and immunosuppressants. Chimeric anti-TNFα has been employed when all other treatments have failed. Isolated cases and short series of cases have been reported. This paper summarizes the available reports on the use, efficacy, and safety of infliximab in the treatment of PUK. Wolters Kluwer Health 2014-12-05 /pmc/articles/PMC4616390/ /pubmed/25474432 http://dx.doi.org/10.1097/MD.0000000000000176 Text en © 2014 Wolters Kluwer Health | Lippincott Williams & Wilkins http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5800 Huerva, Valentín Ascaso, Francisco J. Grzybowski, Andrzej Infliximab for Peripheral Ulcerative Keratitis Treatment |
title | Infliximab for Peripheral Ulcerative Keratitis Treatment |
title_full | Infliximab for Peripheral Ulcerative Keratitis Treatment |
title_fullStr | Infliximab for Peripheral Ulcerative Keratitis Treatment |
title_full_unstemmed | Infliximab for Peripheral Ulcerative Keratitis Treatment |
title_short | Infliximab for Peripheral Ulcerative Keratitis Treatment |
title_sort | infliximab for peripheral ulcerative keratitis treatment |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616390/ https://www.ncbi.nlm.nih.gov/pubmed/25474432 http://dx.doi.org/10.1097/MD.0000000000000176 |
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