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Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study
Diabetic macular edema (DME) is the main cause of visual loss associated with diabetes but any association between DME and cardiovascular events is unclear. This study aims to describe the possible association between DME and cardiovascular events in a multicenter cross-sectional study of patients w...
Autores principales: | , , , , , , , , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616429/ https://www.ncbi.nlm.nih.gov/pubmed/26287408 http://dx.doi.org/10.1097/MD.0000000000001220 |
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author | Leveziel, Nicolas Ragot, Stéphanie Gand, Elise Lichtwitz, Olivier Halimi, Jean Michel Gozlan, Julien Gourdy, Pierre Robert, Marie-Françoise Dardari, Dured Boissonnot, Michèle Roussel, Ronan Piguel, Xavier Dupuy, Olivier Torremocha, Florence Saulnier, Pierre-Jean Maréchaud, Richard Hadjadj, Samy |
author_facet | Leveziel, Nicolas Ragot, Stéphanie Gand, Elise Lichtwitz, Olivier Halimi, Jean Michel Gozlan, Julien Gourdy, Pierre Robert, Marie-Françoise Dardari, Dured Boissonnot, Michèle Roussel, Ronan Piguel, Xavier Dupuy, Olivier Torremocha, Florence Saulnier, Pierre-Jean Maréchaud, Richard Hadjadj, Samy |
author_sort | Leveziel, Nicolas |
collection | PubMed |
description | Diabetic macular edema (DME) is the main cause of visual loss associated with diabetes but any association between DME and cardiovascular events is unclear. This study aims to describe the possible association between DME and cardiovascular events in a multicenter cross-sectional study of patients with type 2 diabetes. Two thousand eight hundred seven patients with type 2 diabetes were recruited from diabetes and nephrology clinical institutional centers participating in the DIAB 2 NEPHROGENE study focusing on diabetic complications. DME (presence/absence) and diabetic retinopathy (DR) classification were based on ophthalmological report and/or on 30° color retinal photographs. DR was defined as absent, nonproliferative (background, moderate, or severe) or proliferative. Cardiovascular events were stroke, myocardial infarction, and lower limb amputation. Details regarding associations between DME and cardiovascular events were evaluated. The study included 2807 patients with type 2 diabetes, of whom 355 (12.6%) had DME. DME was significantly and independently associated with patient age, known duration of diabetes, HbA1c, systolic blood pressure, and DR stage. Only the prior history of lower limb amputation was strongly associated with DME in univariate and multivariate analyses, whereas no association was found with regard to myocardial infarction or stroke. Moreover, both major (n = 32) and minor lower limb (n = 96) amputations were similarly associated with DME, with respective odds ratio of 3.7 (95% confidence interval [CI], 1.77–7.74; P = 0.0012) and of 4.29 (95% CI, 2.79–6.61; P < 0.001). DME is strongly and independently associated with lower limb amputation in type 2 diabetic patients. |
format | Online Article Text |
id | pubmed-4616429 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46164292015-10-27 Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study Leveziel, Nicolas Ragot, Stéphanie Gand, Elise Lichtwitz, Olivier Halimi, Jean Michel Gozlan, Julien Gourdy, Pierre Robert, Marie-Françoise Dardari, Dured Boissonnot, Michèle Roussel, Ronan Piguel, Xavier Dupuy, Olivier Torremocha, Florence Saulnier, Pierre-Jean Maréchaud, Richard Hadjadj, Samy Medicine (Baltimore) 5800 Diabetic macular edema (DME) is the main cause of visual loss associated with diabetes but any association between DME and cardiovascular events is unclear. This study aims to describe the possible association between DME and cardiovascular events in a multicenter cross-sectional study of patients with type 2 diabetes. Two thousand eight hundred seven patients with type 2 diabetes were recruited from diabetes and nephrology clinical institutional centers participating in the DIAB 2 NEPHROGENE study focusing on diabetic complications. DME (presence/absence) and diabetic retinopathy (DR) classification were based on ophthalmological report and/or on 30° color retinal photographs. DR was defined as absent, nonproliferative (background, moderate, or severe) or proliferative. Cardiovascular events were stroke, myocardial infarction, and lower limb amputation. Details regarding associations between DME and cardiovascular events were evaluated. The study included 2807 patients with type 2 diabetes, of whom 355 (12.6%) had DME. DME was significantly and independently associated with patient age, known duration of diabetes, HbA1c, systolic blood pressure, and DR stage. Only the prior history of lower limb amputation was strongly associated with DME in univariate and multivariate analyses, whereas no association was found with regard to myocardial infarction or stroke. Moreover, both major (n = 32) and minor lower limb (n = 96) amputations were similarly associated with DME, with respective odds ratio of 3.7 (95% confidence interval [CI], 1.77–7.74; P = 0.0012) and of 4.29 (95% CI, 2.79–6.61; P < 0.001). DME is strongly and independently associated with lower limb amputation in type 2 diabetic patients. Wolters Kluwer Health 2015-08-21 /pmc/articles/PMC4616429/ /pubmed/26287408 http://dx.doi.org/10.1097/MD.0000000000001220 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0 |
spellingShingle | 5800 Leveziel, Nicolas Ragot, Stéphanie Gand, Elise Lichtwitz, Olivier Halimi, Jean Michel Gozlan, Julien Gourdy, Pierre Robert, Marie-Françoise Dardari, Dured Boissonnot, Michèle Roussel, Ronan Piguel, Xavier Dupuy, Olivier Torremocha, Florence Saulnier, Pierre-Jean Maréchaud, Richard Hadjadj, Samy Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title_full | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title_fullStr | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title_full_unstemmed | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title_short | Association Between Diabetic Macular Edema and Cardiovascular Events in Type 2 Diabetes Patients: A Multicenter Observational Study |
title_sort | association between diabetic macular edema and cardiovascular events in type 2 diabetes patients: a multicenter observational study |
topic | 5800 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616429/ https://www.ncbi.nlm.nih.gov/pubmed/26287408 http://dx.doi.org/10.1097/MD.0000000000001220 |
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