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Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease
Neurodegenerative disease in patients with chronic obstructive pulmonary disease (COPD) was observed. We aim to clarify the risk of dementia in patients with COPD. The study used claims data from Taiwan's National Health Insurance Research Database. Subjects were those who received a discharge...
Autores principales: | , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616489/ https://www.ncbi.nlm.nih.gov/pubmed/26061317 http://dx.doi.org/10.1097/MD.0000000000000930 |
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author | Liao, Kuang-Ming Ho, Chung-Han Ko, Shian-Chin Li, Chung-Yi |
author_facet | Liao, Kuang-Ming Ho, Chung-Han Ko, Shian-Chin Li, Chung-Yi |
author_sort | Liao, Kuang-Ming |
collection | PubMed |
description | Neurodegenerative disease in patients with chronic obstructive pulmonary disease (COPD) was observed. We aim to clarify the risk of dementia in patients with COPD. The study used claims data from Taiwan's National Health Insurance Research Database. Subjects were those who received a discharge diagnosis of COPD between January 1, 2002 and December 31, 2011. Only the first hospitalization was enrolled, and the index date was the first day of admission. Patients younger than 40 years or those with a history of Alzheimer disease (AD) or Parkinson disease (PD) before the index date were excluded. The patients with COPD were then followed until receiving a diagnosis of AD or PD, death, or the end of the study. Control subjects were selected from hospitalized patients without a history of COPD, AD, or PD and were matched according to age (±3 years), gender, and the year of admission at a 2:1 ratio. The comorbidities were measured from 1 year before the index date based on the ICD-9-CM codes. The study included 8640 patients with COPD and a mean age of 68.76 (±10.74) years. The adjusted hazard ratio of developing dementia (AD or PD) was 1.74 (95% confidence interval = 1.55–1.96) in patients with COPD compared with patients without COPD after adjusting for age, gender, and comorbidities. This nationwide cohort study demonstrates that the risk of dementia, including AD and PD, is significantly increased in patients with COPD compared with individuals in the general population. |
format | Online Article Text |
id | pubmed-4616489 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46164892015-10-27 Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease Liao, Kuang-Ming Ho, Chung-Han Ko, Shian-Chin Li, Chung-Yi Medicine (Baltimore) 6700 Neurodegenerative disease in patients with chronic obstructive pulmonary disease (COPD) was observed. We aim to clarify the risk of dementia in patients with COPD. The study used claims data from Taiwan's National Health Insurance Research Database. Subjects were those who received a discharge diagnosis of COPD between January 1, 2002 and December 31, 2011. Only the first hospitalization was enrolled, and the index date was the first day of admission. Patients younger than 40 years or those with a history of Alzheimer disease (AD) or Parkinson disease (PD) before the index date were excluded. The patients with COPD were then followed until receiving a diagnosis of AD or PD, death, or the end of the study. Control subjects were selected from hospitalized patients without a history of COPD, AD, or PD and were matched according to age (±3 years), gender, and the year of admission at a 2:1 ratio. The comorbidities were measured from 1 year before the index date based on the ICD-9-CM codes. The study included 8640 patients with COPD and a mean age of 68.76 (±10.74) years. The adjusted hazard ratio of developing dementia (AD or PD) was 1.74 (95% confidence interval = 1.55–1.96) in patients with COPD compared with patients without COPD after adjusting for age, gender, and comorbidities. This nationwide cohort study demonstrates that the risk of dementia, including AD and PD, is significantly increased in patients with COPD compared with individuals in the general population. Wolters Kluwer Health 2015-06-12 /pmc/articles/PMC4616489/ /pubmed/26061317 http://dx.doi.org/10.1097/MD.0000000000000930 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 6700 Liao, Kuang-Ming Ho, Chung-Han Ko, Shian-Chin Li, Chung-Yi Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title | Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title_full | Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title_fullStr | Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title_full_unstemmed | Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title_short | Increased Risk of Dementia in Patients With Chronic Obstructive Pulmonary Disease |
title_sort | increased risk of dementia in patients with chronic obstructive pulmonary disease |
topic | 6700 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616489/ https://www.ncbi.nlm.nih.gov/pubmed/26061317 http://dx.doi.org/10.1097/MD.0000000000000930 |
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