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Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis
The house dust mite is one of the most common allergens worldwide. There is good evidence that house dust mite subcutaneous immunotherapy is efficacious and has long-term benefit in children. However, the evidence of the benefit of house dust mite sublingual immunotherapy (SLIT) is less convincing....
Autores principales: | , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer Health
2015
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616527/ https://www.ncbi.nlm.nih.gov/pubmed/26091451 http://dx.doi.org/10.1097/MD.0000000000000701 |
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author | Liao, Wei Hu, Qi Shen, Lei-Lei Hu, Ying Tao, Hai-feng Li, Hui-fan Fan, Wen-ting |
author_facet | Liao, Wei Hu, Qi Shen, Lei-Lei Hu, Ying Tao, Hai-feng Li, Hui-fan Fan, Wen-ting |
author_sort | Liao, Wei |
collection | PubMed |
description | The house dust mite is one of the most common allergens worldwide. There is good evidence that house dust mite subcutaneous immunotherapy is efficacious and has long-term benefit in children. However, the evidence of the benefit of house dust mite sublingual immunotherapy (SLIT) is less convincing. The purpose of this meta-analysis was to evaluate that efficacy and safety of dust mite SLIT in children with asthma. Medical Literature Analysis and Retrieval System Online, ISI Web of Knowledge, and Cochrane Central Register of Controlled Trials databases until February 2014 were searched. The primary outcome was mean change in asthma symptom score. Secondary outcomes included mean change in serum immunoglobulin G4 (sIgG4), specific Dermatophagoides pteronyssinus, immunoglobulin E (IgE) levels, and medication score. Safety was also assessed. We found that SLIT significantly decreased asthma symptom score (P = 0.007) and increased sIgG4 levels (P = 0.011) greater than control in children (<18 years of age) with asthma. There was no difference between SLIT and control groups in specific D pteronyssinus IgE levels (P = 0.076) and medication score (P = 0.408). The safety profile was similar between groups. Our study indicates that dust mite SLIT therapy was effective in reducing asthma symptoms and in increasing sIgG4 but did not significantly reduce medication scores or specific D pteronyssinus IgE levels. Our findings are not enough to support the use of dust mite SLIT in children with asthma. |
format | Online Article Text |
id | pubmed-4616527 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Wolters Kluwer Health |
record_format | MEDLINE/PubMed |
spelling | pubmed-46165272015-10-27 Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis Liao, Wei Hu, Qi Shen, Lei-Lei Hu, Ying Tao, Hai-feng Li, Hui-fan Fan, Wen-ting Medicine (Baltimore) 3600 The house dust mite is one of the most common allergens worldwide. There is good evidence that house dust mite subcutaneous immunotherapy is efficacious and has long-term benefit in children. However, the evidence of the benefit of house dust mite sublingual immunotherapy (SLIT) is less convincing. The purpose of this meta-analysis was to evaluate that efficacy and safety of dust mite SLIT in children with asthma. Medical Literature Analysis and Retrieval System Online, ISI Web of Knowledge, and Cochrane Central Register of Controlled Trials databases until February 2014 were searched. The primary outcome was mean change in asthma symptom score. Secondary outcomes included mean change in serum immunoglobulin G4 (sIgG4), specific Dermatophagoides pteronyssinus, immunoglobulin E (IgE) levels, and medication score. Safety was also assessed. We found that SLIT significantly decreased asthma symptom score (P = 0.007) and increased sIgG4 levels (P = 0.011) greater than control in children (<18 years of age) with asthma. There was no difference between SLIT and control groups in specific D pteronyssinus IgE levels (P = 0.076) and medication score (P = 0.408). The safety profile was similar between groups. Our study indicates that dust mite SLIT therapy was effective in reducing asthma symptoms and in increasing sIgG4 but did not significantly reduce medication scores or specific D pteronyssinus IgE levels. Our findings are not enough to support the use of dust mite SLIT in children with asthma. Wolters Kluwer Health 2015-06-19 /pmc/articles/PMC4616527/ /pubmed/26091451 http://dx.doi.org/10.1097/MD.0000000000000701 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0 |
spellingShingle | 3600 Liao, Wei Hu, Qi Shen, Lei-Lei Hu, Ying Tao, Hai-feng Li, Hui-fan Fan, Wen-ting Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title | Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title_full | Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title_fullStr | Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title_full_unstemmed | Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title_short | Sublingual Immunotherapy for Asthmatic Children Sensitized to House Dust Mite: A Meta-Analysis |
title_sort | sublingual immunotherapy for asthmatic children sensitized to house dust mite: a meta-analysis |
topic | 3600 |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616527/ https://www.ncbi.nlm.nih.gov/pubmed/26091451 http://dx.doi.org/10.1097/MD.0000000000000701 |
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