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Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study

The relationship between type 2 diabetes and gout is complex. The objective of this study was to understand the role of diabetes itself and its comorbidities within the association between type 2 diabetes and gout. We conducted a retrospective cohort study using the UK Clinical Practice Research Dat...

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Autores principales: Wijnands, José Maria Andreas, van Durme, Caroline Marie Pierre Ghislaine, Driessen, Johanna Hendrika Maria, Boonen, Annelies, Klop, Corinne, Leufkens, Bert, Cooper, Cyrus, Stehouwer, Coen Dirk Adriaan, de Vries, Frank
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616721/
https://www.ncbi.nlm.nih.gov/pubmed/26266391
http://dx.doi.org/10.1097/MD.0000000000001358
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author Wijnands, José Maria Andreas
van Durme, Caroline Marie Pierre Ghislaine
Driessen, Johanna Hendrika Maria
Boonen, Annelies
Klop, Corinne
Leufkens, Bert
Cooper, Cyrus
Stehouwer, Coen Dirk Adriaan
de Vries, Frank
author_facet Wijnands, José Maria Andreas
van Durme, Caroline Marie Pierre Ghislaine
Driessen, Johanna Hendrika Maria
Boonen, Annelies
Klop, Corinne
Leufkens, Bert
Cooper, Cyrus
Stehouwer, Coen Dirk Adriaan
de Vries, Frank
author_sort Wijnands, José Maria Andreas
collection PubMed
description The relationship between type 2 diabetes and gout is complex. The objective of this study was to understand the role of diabetes itself and its comorbidities within the association between type 2 diabetes and gout. We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (CPRD) GOLD. Persons with type 2 diabetes were identified as persons on a noninsulin antidiabetic drug (NIAD) between 2004 and 2012, and were matched to 1 control based on age, sex, and general practice. We estimated gout risk in NIAD users using Cox regression analysis. All analyses were stratified for sex. In total, 221,117 NIAD users were identified. NIAD users had an increased risk of gout (hazard ratio (HR) 1.48; 95% CI 1.41–1.54). This association was stronger in women (HR 2.23; 95% CI 2.07–2.41) compared with men (HR 1.19; 95% CI 1.13–1.26). After adjustments for BMI, eGFR, hypertension, renal transplantation, diuretics, statins, low-dose aspirin, ciclosporin, and tacrolimus, the risk disappeared in women (HR 1.01; 95% CI 0.92–1.11) and reversed in men (HR 0.61; 95% CI 0.58–0.66) (P for interaction <0.001). When stratifying gout risk according to HbA1c in male and female NIAD users, we found an inverse association between raising HbA1c and incident gout in men only. Further adjustment gave similar results. Individuals with type 2 diabetes are at increased risk of gout. This is not due to diabetes itself, but to the comorbid conditions. Diabetes itself is apparently associated with a decreased risk of gout, especially in men.
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spelling pubmed-46167212015-10-27 Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study Wijnands, José Maria Andreas van Durme, Caroline Marie Pierre Ghislaine Driessen, Johanna Hendrika Maria Boonen, Annelies Klop, Corinne Leufkens, Bert Cooper, Cyrus Stehouwer, Coen Dirk Adriaan de Vries, Frank Medicine (Baltimore) 6900 The relationship between type 2 diabetes and gout is complex. The objective of this study was to understand the role of diabetes itself and its comorbidities within the association between type 2 diabetes and gout. We conducted a retrospective cohort study using the UK Clinical Practice Research Datalink (CPRD) GOLD. Persons with type 2 diabetes were identified as persons on a noninsulin antidiabetic drug (NIAD) between 2004 and 2012, and were matched to 1 control based on age, sex, and general practice. We estimated gout risk in NIAD users using Cox regression analysis. All analyses were stratified for sex. In total, 221,117 NIAD users were identified. NIAD users had an increased risk of gout (hazard ratio (HR) 1.48; 95% CI 1.41–1.54). This association was stronger in women (HR 2.23; 95% CI 2.07–2.41) compared with men (HR 1.19; 95% CI 1.13–1.26). After adjustments for BMI, eGFR, hypertension, renal transplantation, diuretics, statins, low-dose aspirin, ciclosporin, and tacrolimus, the risk disappeared in women (HR 1.01; 95% CI 0.92–1.11) and reversed in men (HR 0.61; 95% CI 0.58–0.66) (P for interaction <0.001). When stratifying gout risk according to HbA1c in male and female NIAD users, we found an inverse association between raising HbA1c and incident gout in men only. Further adjustment gave similar results. Individuals with type 2 diabetes are at increased risk of gout. This is not due to diabetes itself, but to the comorbid conditions. Diabetes itself is apparently associated with a decreased risk of gout, especially in men. Wolters Kluwer Health 2015-08-14 /pmc/articles/PMC4616721/ /pubmed/26266391 http://dx.doi.org/10.1097/MD.0000000000001358 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 6900
Wijnands, José Maria Andreas
van Durme, Caroline Marie Pierre Ghislaine
Driessen, Johanna Hendrika Maria
Boonen, Annelies
Klop, Corinne
Leufkens, Bert
Cooper, Cyrus
Stehouwer, Coen Dirk Adriaan
de Vries, Frank
Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title_full Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title_fullStr Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title_full_unstemmed Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title_short Individuals With Type 2 Diabetes Mellitus Are at an Increased Risk of Gout But This Is Not Due to Diabetes: A Population-Based Cohort Study
title_sort individuals with type 2 diabetes mellitus are at an increased risk of gout but this is not due to diabetes: a population-based cohort study
topic 6900
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616721/
https://www.ncbi.nlm.nih.gov/pubmed/26266391
http://dx.doi.org/10.1097/MD.0000000000001358
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