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SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy

Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. A total of 254 HCC patients and 354 healthy...

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Autores principales: Jiang, Bei-ge, Yang, Yuan, Liu, Hui, Gu, Fang-ming, Yang, Yun, Zhao, Lin-Hao, Yuan, Sheng-xian, Wang, Ruo-yu, Zhang, Jin, Zhou, Wei-ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616756/
https://www.ncbi.nlm.nih.gov/pubmed/26447993
http://dx.doi.org/10.1097/MD.0000000000001344
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author Jiang, Bei-ge
Yang, Yuan
Liu, Hui
Gu, Fang-ming
Yang, Yun
Zhao, Lin-Hao
Yuan, Sheng-xian
Wang, Ruo-yu
Zhang, Jin
Zhou, Wei-ping
author_facet Jiang, Bei-ge
Yang, Yuan
Liu, Hui
Gu, Fang-ming
Yang, Yun
Zhao, Lin-Hao
Yuan, Sheng-xian
Wang, Ruo-yu
Zhang, Jin
Zhou, Wei-ping
author_sort Jiang, Bei-ge
collection PubMed
description Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. A total of 254 HCC patients and 354 healthy controls were enrolled. All HCC patients underwent partial hepatectomy as initial treatment and were followed. Three SOCS3 gene polymorphisms, namely, rs4969170 A>G, rs8064821 C>T, and rs12953258 C>A were determined. Our data show that the rs4969170 A>G polymorphism dramatically affects the susceptibility to HCC in our cohorts. Logistic regression analyses revealed that the rs4969170 GG is a risk factor for HCC after the adjustment with confounding factors. The rs4969170A>G polymorphism is also associated with the clinical features of HCC patients and predicts the postoperative relapse-free survival and overall survival. The rs4969170GG genotype carrier had a worse prognosis than the rs4969170AG and rs4969170AA carrier. Our findings suggest that the rs4969170A>G polymorphism of SOCS3 gene may be used as a prognostic predictor for HCC patients who underwent surgical treatment.
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spelling pubmed-46167562015-10-27 SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy Jiang, Bei-ge Yang, Yuan Liu, Hui Gu, Fang-ming Yang, Yun Zhao, Lin-Hao Yuan, Sheng-xian Wang, Ruo-yu Zhang, Jin Zhou, Wei-ping Medicine (Baltimore) 5700 Previous studies showed that suppressor of cytokine signaling 3 (SOCS3) protein is associated with incidence and progression of hepatocellular carcinoma (HCC); however, the association between the genetic polymorphism of SOCS3 gene and HCC remains unknown. A total of 254 HCC patients and 354 healthy controls were enrolled. All HCC patients underwent partial hepatectomy as initial treatment and were followed. Three SOCS3 gene polymorphisms, namely, rs4969170 A>G, rs8064821 C>T, and rs12953258 C>A were determined. Our data show that the rs4969170 A>G polymorphism dramatically affects the susceptibility to HCC in our cohorts. Logistic regression analyses revealed that the rs4969170 GG is a risk factor for HCC after the adjustment with confounding factors. The rs4969170A>G polymorphism is also associated with the clinical features of HCC patients and predicts the postoperative relapse-free survival and overall survival. The rs4969170GG genotype carrier had a worse prognosis than the rs4969170AG and rs4969170AA carrier. Our findings suggest that the rs4969170A>G polymorphism of SOCS3 gene may be used as a prognostic predictor for HCC patients who underwent surgical treatment. Wolters Kluwer Health 2015-10-09 /pmc/articles/PMC4616756/ /pubmed/26447993 http://dx.doi.org/10.1097/MD.0000000000001344 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by/4.0 This is an open access article distributed under the Creative Commons Attribution License 4.0, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. http://creativecommons.org/licenses/by/4.0
spellingShingle 5700
Jiang, Bei-ge
Yang, Yuan
Liu, Hui
Gu, Fang-ming
Yang, Yun
Zhao, Lin-Hao
Yuan, Sheng-xian
Wang, Ruo-yu
Zhang, Jin
Zhou, Wei-ping
SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title_full SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title_fullStr SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title_full_unstemmed SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title_short SOCS3 Genetic Polymorphism Is Associated With Clinical Features and Prognosis of Hepatocellular Carcinoma Patients Receiving Hepatectomy
title_sort socs3 genetic polymorphism is associated with clinical features and prognosis of hepatocellular carcinoma patients receiving hepatectomy
topic 5700
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616756/
https://www.ncbi.nlm.nih.gov/pubmed/26447993
http://dx.doi.org/10.1097/MD.0000000000001344
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