CT Characteristic of Early Local Recurrence After Resection of the Squamous Cell Carcinoma: Comparison With CT Characteristics of Stump Deformity or Granulation Tissue at Stump Site

The aim of this study is to compare the thin section computed tomography (CT) characteristics of the early local tumor recurrence with those of the stump deformity or granulation tissue after the resection of squamous cell carcinoma (SCC). Twenty-nine consecutive patients with local recurrence after definitive SCC operation from April 2006 to September 2012 were included in our study. Pre- and postoperative CT findings from these patients were retrospectively reviewed and compared with those in the age- and sex-matched 29 patients with the stump deformity or granulation tissue at stump site after definitive SCC operation, by 2 radiologists. We evaluated the initial tumor stage, tumor size, and tumor location in relation with the bronchus on preoperative CT scan. On postoperative CT scan, we evaluated the size, CT characteristics, and involvement pattern of the suspected soft tissue around the stump site, and the distance between surgical staples and soft tissue at the stump site. Tumor stage, tumor size, and tumor location in relation with the bronchus on preoperative CT scan were not significantly different between 2 groups, while lymph node stage was more advanced in the local recurrence group. On postoperative CT scan, the size of suspected soft tissue at stump site is significantly larger, and the distance between stump staples and suspected soft tissue was significantly longer in the local recurrence group than control group (median; 19 mm and 3 mm; 18 mm and 0 mm, respectively, P < 0.001). The univariate analysis showed that the size of soft tissue and the distance between soft tissue and stump site on postoperative CT scan were associated with the predictive factors of local recurrence (P < 0.001). On the receiver-operating characteristic analysis, the optimal cutoffs of the size of soft tissue and the distance between soft tissue and stump staples for determining local tumor recurrence were 6 and 5 mm, respectively. The proper knowledge CT characteristics of local tumor recurrence including the soft tissue size (cut-off, 6 mm) and the distance (cut-off, 5 mm) between soft tissue and stump site will help us achieve the early diagnosis and higher diagnostic rate of locally recurred SCC.