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Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study

Studies have suggested that statin use is related to cancer risk and prostate cancer mortality. We conducted a population-based cohort study to determine whether using statins in prostate cancer patients is associated with reduced all-cause mortality rates. Data were obtained from the Taiwan Nationa...

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Autores principales: Sun, Li-Min, Lin, Ming-Chia, Lin, Cheng-Li, Chang, Shih-Ni, Liang, Ji-An, Lin, I-Ching, Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616817/
https://www.ncbi.nlm.nih.gov/pubmed/26426656
http://dx.doi.org/10.1097/MD.0000000000001644
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author Sun, Li-Min
Lin, Ming-Chia
Lin, Cheng-Li
Chang, Shih-Ni
Liang, Ji-An
Lin, I-Ching
Kao, Chia-Hung
author_facet Sun, Li-Min
Lin, Ming-Chia
Lin, Cheng-Li
Chang, Shih-Ni
Liang, Ji-An
Lin, I-Ching
Kao, Chia-Hung
author_sort Sun, Li-Min
collection PubMed
description Studies have suggested that statin use is related to cancer risk and prostate cancer mortality. We conducted a population-based cohort study to determine whether using statins in prostate cancer patients is associated with reduced all-cause mortality rates. Data were obtained from the Taiwan National Health Insurance Research Database. The study cohort comprised 5179 patients diagnosed with prostate cancer who used statins for at least 6 months between January 1, 1998 and December 31, 2010. To form a comparison group, each patient was randomly frequency-matched (according to age and index date) with a prostate cancer patient who did not use any type of statin-based drugs during the study period. The study endpoint was mortality. The hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox regression models. Among prostate cancer patients, statin use was associated with significantly decreased all-cause mortality (adjusted HR = 0.65; 95% CI = 0.60–0.71). This phenomenon was observed among various types of statin, age groups, and treatment methods. Analyzing the defined daily dose of statins indicated that both low- and high-dose groups exhibited significantly decreased death rates compared with nonusers, suggesting a dose–response relationship. The results of this population-based cohort study suggest that using statins reduces all-cause mortality among prostate cancer patients, and a dose–response relationship may exist.
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spelling pubmed-46168172015-10-27 Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study Sun, Li-Min Lin, Ming-Chia Lin, Cheng-Li Chang, Shih-Ni Liang, Ji-An Lin, I-Ching Kao, Chia-Hung Medicine (Baltimore) 7300 Studies have suggested that statin use is related to cancer risk and prostate cancer mortality. We conducted a population-based cohort study to determine whether using statins in prostate cancer patients is associated with reduced all-cause mortality rates. Data were obtained from the Taiwan National Health Insurance Research Database. The study cohort comprised 5179 patients diagnosed with prostate cancer who used statins for at least 6 months between January 1, 1998 and December 31, 2010. To form a comparison group, each patient was randomly frequency-matched (according to age and index date) with a prostate cancer patient who did not use any type of statin-based drugs during the study period. The study endpoint was mortality. The hazard ratio (HR) and 95% confidence interval (CI) were estimated using Cox regression models. Among prostate cancer patients, statin use was associated with significantly decreased all-cause mortality (adjusted HR = 0.65; 95% CI = 0.60–0.71). This phenomenon was observed among various types of statin, age groups, and treatment methods. Analyzing the defined daily dose of statins indicated that both low- and high-dose groups exhibited significantly decreased death rates compared with nonusers, suggesting a dose–response relationship. The results of this population-based cohort study suggest that using statins reduces all-cause mortality among prostate cancer patients, and a dose–response relationship may exist. Wolters Kluwer Health 2015-10-02 /pmc/articles/PMC4616817/ /pubmed/26426656 http://dx.doi.org/10.1097/MD.0000000000001644 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nc-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0, where it is permissible to download, share and reproduce the work in any medium, provided it is properly cited. The work cannot be changed in any way or used commercially. http://creativecommons.org/licenses/by-nc-nd/4.0
spellingShingle 7300
Sun, Li-Min
Lin, Ming-Chia
Lin, Cheng-Li
Chang, Shih-Ni
Liang, Ji-An
Lin, I-Ching
Kao, Chia-Hung
Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title_full Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title_fullStr Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title_full_unstemmed Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title_short Statin Use Reduces Prostate Cancer All-Cause Mortality: A Nationwide Population-Based Cohort Study
title_sort statin use reduces prostate cancer all-cause mortality: a nationwide population-based cohort study
topic 7300
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616817/
https://www.ncbi.nlm.nih.gov/pubmed/26426656
http://dx.doi.org/10.1097/MD.0000000000001644
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