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Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies

Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transpla...

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Autores principales: Lee, Juhan, Oh, Young Taik, Joo, Dong Jin, Ma, Bo Gyoung, Lee, A-lan, Lee, Jae Geun, Song, Seung Hwan, Kim, Seung Up, Jung, Dae Chul, Chung, Yong Eun, Kim, Yu Seun
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616853/
https://www.ncbi.nlm.nih.gov/pubmed/26426636
http://dx.doi.org/10.1097/MD.0000000000001590
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author Lee, Juhan
Oh, Young Taik
Joo, Dong Jin
Ma, Bo Gyoung
Lee, A-lan
Lee, Jae Geun
Song, Seung Hwan
Kim, Seung Up
Jung, Dae Chul
Chung, Yong Eun
Kim, Yu Seun
author_facet Lee, Juhan
Oh, Young Taik
Joo, Dong Jin
Ma, Bo Gyoung
Lee, A-lan
Lee, Jae Geun
Song, Seung Hwan
Kim, Seung Up
Jung, Dae Chul
Chung, Yong Eun
Kim, Yu Seun
author_sort Lee, Juhan
collection PubMed
description Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P < 0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r = −0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values.
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spelling pubmed-46168532015-10-27 Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies Lee, Juhan Oh, Young Taik Joo, Dong Jin Ma, Bo Gyoung Lee, A-lan Lee, Jae Geun Song, Seung Hwan Kim, Seung Up Jung, Dae Chul Chung, Yong Eun Kim, Yu Seun Medicine (Baltimore) 5200 Interstitial fibrosis and tubular atrophy (IF/TA) is a common cause of kidney allograft loss. Several noninvasive techniques developed to assess tissue fibrosis are widely used to examine the liver. However, relatively few studies have investigated the use of elastographic methods to assess transplanted kidneys. The aim of this study was to explore the clinical implications of the acoustic radiation force impulse (ARFI) technique in renal transplant patients. A total of 91 patients who underwent living donor renal transplantation between September 2010 and January 2013 were included in this prospective study. Shear wave velocity (SWV) was measured by ARFI at baseline and predetermined time points (1 week and 6 and 12 months after transplantation). Protocol biopsies were performed at 12 months. Instead of reflecting IF/TA, SWVs were found to be related to time elapsed after transplantation. Mean SWV increased continuously during the first postoperative year (P < 0.001). In addition, mixed model analysis showed no correlation existed between SWV and serum creatinine (r = −0.2426, P = 0.0771). There was also no evidence of a relationship between IF/TA and serum creatinine (odds ratio [OR] = 1.220, P = 0.7648). Furthermore, SWV temporal patterns were dependent on the kidney weight to body weight ratio (KW/BW). In patients with a KW/BW <3.5 g/kg, mean SWV continuously increased for 12 months, whereas it decreased after 6 months in those with a KW/BW ≥3.5 g/kg. No significant correlation was observed between SWV and IF/TA or renal dysfunction. However, SWV was found to be related to the time after transplantation. Renal hemodynamics influenced by KW/BW might impact SWV values. Wolters Kluwer Health 2015-10-02 /pmc/articles/PMC4616853/ /pubmed/26426636 http://dx.doi.org/10.1097/MD.0000000000001590 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5200
Lee, Juhan
Oh, Young Taik
Joo, Dong Jin
Ma, Bo Gyoung
Lee, A-lan
Lee, Jae Geun
Song, Seung Hwan
Kim, Seung Up
Jung, Dae Chul
Chung, Yong Eun
Kim, Yu Seun
Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title_full Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title_fullStr Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title_full_unstemmed Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title_short Acoustic Radiation Force Impulse Measurement in Renal Transplantation: A Prospective, Longitudinal Study With Protocol Biopsies
title_sort acoustic radiation force impulse measurement in renal transplantation: a prospective, longitudinal study with protocol biopsies
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616853/
https://www.ncbi.nlm.nih.gov/pubmed/26426636
http://dx.doi.org/10.1097/MD.0000000000001590
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