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SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER

The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), a...

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Autores principales: SOUNDRAVALLY, Rajendiran, SHERIN, Jacob, AGIESHKUMAR, Balakrishna Pillai, DAISY, Mariya Samadanam, CLEETUS, Cherupanakkal, NARAYANAN, Parameswaran, KADHIRAVAN, Tamilarasu, SUJATHA, Sistla, HARICHANDRAKUMAR, Kottyen Thazhath
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Instituto de Medicina Tropical 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616916/
https://www.ncbi.nlm.nih.gov/pubmed/26422155
http://dx.doi.org/10.1590/S0036-46652015000400007
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author SOUNDRAVALLY, Rajendiran
SHERIN, Jacob
AGIESHKUMAR, Balakrishna Pillai
DAISY, Mariya Samadanam
CLEETUS, Cherupanakkal
NARAYANAN, Parameswaran
KADHIRAVAN, Tamilarasu
SUJATHA, Sistla
HARICHANDRAKUMAR, Kottyen Thazhath
author_facet SOUNDRAVALLY, Rajendiran
SHERIN, Jacob
AGIESHKUMAR, Balakrishna Pillai
DAISY, Mariya Samadanam
CLEETUS, Cherupanakkal
NARAYANAN, Parameswaran
KADHIRAVAN, Tamilarasu
SUJATHA, Sistla
HARICHANDRAKUMAR, Kottyen Thazhath
author_sort SOUNDRAVALLY, Rajendiran
collection PubMed
description The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue.
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spelling pubmed-46169162015-11-03 SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER SOUNDRAVALLY, Rajendiran SHERIN, Jacob AGIESHKUMAR, Balakrishna Pillai DAISY, Mariya Samadanam CLEETUS, Cherupanakkal NARAYANAN, Parameswaran KADHIRAVAN, Tamilarasu SUJATHA, Sistla HARICHANDRAKUMAR, Kottyen Thazhath Rev Inst Med Trop Sao Paulo Virology The role of trace elements in dengue virulence is not yet known. The present study assessed the serum levels of two micronutrients, copper and iron, in cases of dengue fever. The study involved 96 patients of whom 48 had either severe or non-severe forms of dengue (with and without warning signs), and the remaining 48 were patients with other febrile illnesses (OFI), used as controls. Serum levels of copper and iron were evaluated at admission and by the time of defervescence using commercially available kits. At admission, no difference in the level of serum copper was observed between cases and controls. In the group of dengue cases, the copper level was found to be significantly decreased in severe and non-severe cases with warning signs, compared to non-severe cases without warning signs. In contrast, by the time of defervescence the copper level was found to be increased in all dengue cases compared to OFI controls, but no difference was observed among dengue cases. Unlike OFI controls, dengue cases showed an increasing pattern of copper levels from admission until defervescence. On the other hand, no such significant differences were observed in the serum level of iron in the clinical groups, except for a decreased iron level found in severe cases, compared to non-severe dengue without warning signs. The results show that copper is associated with dengue severity and this finding emphasizes the need to investigate the involvement of trace elements in disease severity so as to improve the prognosis of dengue. Instituto de Medicina Tropical 2015 /pmc/articles/PMC4616916/ /pubmed/26422155 http://dx.doi.org/10.1590/S0036-46652015000400007 Text en http://creativecommons.org/licenses/by-nc/4.0 This is an open-access article distributed under the terms of the Creative Commons Attribution License
spellingShingle Virology
SOUNDRAVALLY, Rajendiran
SHERIN, Jacob
AGIESHKUMAR, Balakrishna Pillai
DAISY, Mariya Samadanam
CLEETUS, Cherupanakkal
NARAYANAN, Parameswaran
KADHIRAVAN, Tamilarasu
SUJATHA, Sistla
HARICHANDRAKUMAR, Kottyen Thazhath
SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title_full SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title_fullStr SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title_full_unstemmed SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title_short SERUM LEVELS OF COPPER AND IRON IN DENGUE FEVER
title_sort serum levels of copper and iron in dengue fever
topic Virology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4616916/
https://www.ncbi.nlm.nih.gov/pubmed/26422155
http://dx.doi.org/10.1590/S0036-46652015000400007
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