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Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study

To investigate the effect of different dialysis modalities on the incidence of peripheral artery occlusive disease (PAOD) among patients with end-stage renal disease (ESRD) in a large population-based cohort study. The cohort study included 26,927 ESRD patients who underwent hemodialysis (17,737 pat...

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Autores principales: Lin, Chin-Sheng, Chen, Sy-Jou, Sung, Chih-Chien, Lin, Cheng-Li, Lin, Shih-Hua, Cheng, Shu-Meng, Wang, I-Kuan, Huang, Wen-Sheng, Kao, Chia-Hung
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer Health 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617093/
https://www.ncbi.nlm.nih.gov/pubmed/26181560
http://dx.doi.org/10.1097/MD.0000000000001164
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author Lin, Chin-Sheng
Chen, Sy-Jou
Sung, Chih-Chien
Lin, Cheng-Li
Lin, Shih-Hua
Cheng, Shu-Meng
Wang, I-Kuan
Huang, Wen-Sheng
Kao, Chia-Hung
author_facet Lin, Chin-Sheng
Chen, Sy-Jou
Sung, Chih-Chien
Lin, Cheng-Li
Lin, Shih-Hua
Cheng, Shu-Meng
Wang, I-Kuan
Huang, Wen-Sheng
Kao, Chia-Hung
author_sort Lin, Chin-Sheng
collection PubMed
description To investigate the effect of different dialysis modalities on the incidence of peripheral artery occlusive disease (PAOD) among patients with end-stage renal disease (ESRD) in a large population-based cohort study. The cohort study included 26,927 ESRD patients who underwent hemodialysis (17,737 patients, hemodialysis [HD] cohort) or peritoneal dialysis (PD, 9190 patients, PD cohort), and 107,588 matched controls between 2000 and 2010. A Cox proportional hazards model was to evaluate the risk of PAOD in the ESRD underwent HD or PD. Based on a mean follow-up period of 2.92, 3.64, and 4.91 years in the PD, HD, and control cohorts, respectively, the incidences of PAOD were 18.1% and 8.10% higher in the HD and PD cohorts, respectively, compared with the control cohort (log-rank test P < 0.001). The patients who underwent HD or PD exhibited a higher risk of PAOD compared with the control cohort regardless of age, sex, and presence or absence of comorbidities. In addition, the incidence of PAOD in the PD cohort and the propensity score-matched HD cohort were 12.4 and 20.7 per 1000 person-years, respectively, with a hazard ratio of 1.92 (95% confidence interval = 1.62–2.28) in HD patients, compared with the PD cohort. This nationwide population-based cohort study suggested a significantly increased risk of PAOD among ESRD patients. Moreover, the PD patients have a lower risk of developing PAOD compared with the HD cohort, indicating the beneficial roles of PD in reducing PAOD risk in ESRD patients.
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spelling pubmed-46170932015-10-27 Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study Lin, Chin-Sheng Chen, Sy-Jou Sung, Chih-Chien Lin, Cheng-Li Lin, Shih-Hua Cheng, Shu-Meng Wang, I-Kuan Huang, Wen-Sheng Kao, Chia-Hung Medicine (Baltimore) 5200 To investigate the effect of different dialysis modalities on the incidence of peripheral artery occlusive disease (PAOD) among patients with end-stage renal disease (ESRD) in a large population-based cohort study. The cohort study included 26,927 ESRD patients who underwent hemodialysis (17,737 patients, hemodialysis [HD] cohort) or peritoneal dialysis (PD, 9190 patients, PD cohort), and 107,588 matched controls between 2000 and 2010. A Cox proportional hazards model was to evaluate the risk of PAOD in the ESRD underwent HD or PD. Based on a mean follow-up period of 2.92, 3.64, and 4.91 years in the PD, HD, and control cohorts, respectively, the incidences of PAOD were 18.1% and 8.10% higher in the HD and PD cohorts, respectively, compared with the control cohort (log-rank test P < 0.001). The patients who underwent HD or PD exhibited a higher risk of PAOD compared with the control cohort regardless of age, sex, and presence or absence of comorbidities. In addition, the incidence of PAOD in the PD cohort and the propensity score-matched HD cohort were 12.4 and 20.7 per 1000 person-years, respectively, with a hazard ratio of 1.92 (95% confidence interval = 1.62–2.28) in HD patients, compared with the PD cohort. This nationwide population-based cohort study suggested a significantly increased risk of PAOD among ESRD patients. Moreover, the PD patients have a lower risk of developing PAOD compared with the HD cohort, indicating the beneficial roles of PD in reducing PAOD risk in ESRD patients. Wolters Kluwer Health 2015-07-17 /pmc/articles/PMC4617093/ /pubmed/26181560 http://dx.doi.org/10.1097/MD.0000000000001164 Text en Copyright © 2015 Wolters Kluwer Health, Inc. All rights reserved. http://creativecommons.org/licenses/by-nd/4.0 This is an open access article distributed under the Creative Commons Attribution-NoDerivatives License 4.0, which allows for redistribution, commercial and non-commercial, as long as it is passed along unchanged and in whole, with credit to the author. http://creativecommons.org/licenses/by-nd/4.0
spellingShingle 5200
Lin, Chin-Sheng
Chen, Sy-Jou
Sung, Chih-Chien
Lin, Cheng-Li
Lin, Shih-Hua
Cheng, Shu-Meng
Wang, I-Kuan
Huang, Wen-Sheng
Kao, Chia-Hung
Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title_full Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title_fullStr Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title_full_unstemmed Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title_short Hemodialysis Is Associated With Increased Peripheral Artery Occlusive Disease Risk Among Patients With End-Stage Renal Disease: A Nationwide Population-Based Cohort Study
title_sort hemodialysis is associated with increased peripheral artery occlusive disease risk among patients with end-stage renal disease: a nationwide population-based cohort study
topic 5200
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617093/
https://www.ncbi.nlm.nih.gov/pubmed/26181560
http://dx.doi.org/10.1097/MD.0000000000001164
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