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A dose-response curve for biodosimetry from a 6 MV electron linear accelerator

Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve...

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Autores principales: Lemos-Pinto, M.M.P., Cadena, M., Santos, N., Fernandes, T.S., Borges, E., Amaral, A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Associação Brasileira de Divulgação Científica 2015
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617117/
https://www.ncbi.nlm.nih.gov/pubmed/26445334
http://dx.doi.org/10.1590/1414-431X20154470
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author Lemos-Pinto, M.M.P.
Cadena, M.
Santos, N.
Fernandes, T.S.
Borges, E.
Amaral, A.
author_facet Lemos-Pinto, M.M.P.
Cadena, M.
Santos, N.
Fernandes, T.S.
Borges, E.
Amaral, A.
author_sort Lemos-Pinto, M.M.P.
collection PubMed
description Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates.
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spelling pubmed-46171172015-11-24 A dose-response curve for biodosimetry from a 6 MV electron linear accelerator Lemos-Pinto, M.M.P. Cadena, M. Santos, N. Fernandes, T.S. Borges, E. Amaral, A. Braz J Med Biol Res IX Meeting of the "Sociedade Brasileira De Biociências Nucleares". Caxambu, Mg, Brazil August 27-30, 2014 Biological dosimetry (biodosimetry) is based on the investigation of radiation-induced biological effects (biomarkers), mainly dicentric chromosomes, in order to correlate them with radiation dose. To interpret the dicentric score in terms of absorbed dose, a calibration curve is needed. Each curve should be constructed with respect to basic physical parameters, such as the type of ionizing radiation characterized by low or high linear energy transfer (LET) and dose rate. This study was designed to obtain dose calibration curves by scoring of dicentric chromosomes in peripheral blood lymphocytes irradiated in vitro with a 6 MV electron linear accelerator (Mevatron M, Siemens, USA). Two software programs, CABAS (Chromosomal Aberration Calculation Software) and Dose Estimate, were used to generate the curve. The two software programs are discussed; the results obtained were compared with each other and with other published low LET radiation curves. Both software programs resulted in identical linear and quadratic terms for the curve presented here, which was in good agreement with published curves for similar radiation quality and dose rates. Associação Brasileira de Divulgação Científica 2015-05-26 /pmc/articles/PMC4617117/ /pubmed/26445334 http://dx.doi.org/10.1590/1414-431X20154470 Text en http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License, which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle IX Meeting of the "Sociedade Brasileira De Biociências Nucleares". Caxambu, Mg, Brazil August 27-30, 2014
Lemos-Pinto, M.M.P.
Cadena, M.
Santos, N.
Fernandes, T.S.
Borges, E.
Amaral, A.
A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title_full A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title_fullStr A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title_full_unstemmed A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title_short A dose-response curve for biodosimetry from a 6 MV electron linear accelerator
title_sort dose-response curve for biodosimetry from a 6 mv electron linear accelerator
topic IX Meeting of the "Sociedade Brasileira De Biociências Nucleares". Caxambu, Mg, Brazil August 27-30, 2014
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617117/
https://www.ncbi.nlm.nih.gov/pubmed/26445334
http://dx.doi.org/10.1590/1414-431X20154470
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