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Macrophage deficiency of Akt2 reduces atherosclerosis in Ldlr null mice

Macrophages play crucial roles in the formation of atherosclerotic lesions. Akt, a serine/threonine protein kinase B, is vital for cell proliferation, migration, and survival. Macrophages express three Akt isoforms, Akt1, Akt2, and Akt3, but the roles of Akt1 and Akt2 in atherosclerosis in vivo rema...

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Detalles Bibliográficos
Autores principales:	Babaev, Vladimir R., Hebron, Katie E., Wiese, Carrie B., Toth, Cynthia L., Ding, Lei, Zhang, Youmin, May, James M., Fazio, Sergio, Vickers, Kasey C., Linton, MacRae F.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	The American Society for Biochemistry and Molecular Biology 2014
Materias:	Research Articles
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617132/ https://www.ncbi.nlm.nih.gov/pubmed/25240046 http://dx.doi.org/10.1194/jlr.M050633

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