Cargando…
Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus
Chronic tinnitus is associated with neuroplastic changes in auditory and non-auditory cortical areas. About 10 years ago, repetitive transcranial magnetic stimulation (rTMS) of auditory and prefrontal cortex was introduced as potential treatment for tinnitus. The resulting changes in tinnitus loudne...
Autores principales: | , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2015
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617176/ https://www.ncbi.nlm.nih.gov/pubmed/26557055 http://dx.doi.org/10.3389/fncel.2015.00421 |
_version_ | 1782396776034074624 |
---|---|
author | Schecklmann, Martin Lehner, Astrid Gollmitzer, Judith Schmidt, Eldrid Schlee, Winfried Langguth, Berthold |
author_facet | Schecklmann, Martin Lehner, Astrid Gollmitzer, Judith Schmidt, Eldrid Schlee, Winfried Langguth, Berthold |
author_sort | Schecklmann, Martin |
collection | PubMed |
description | Chronic tinnitus is associated with neuroplastic changes in auditory and non-auditory cortical areas. About 10 years ago, repetitive transcranial magnetic stimulation (rTMS) of auditory and prefrontal cortex was introduced as potential treatment for tinnitus. The resulting changes in tinnitus loudness are interpreted in the context of rTMS induced activity changes (neuroplasticity). Here, we investigate the effect of single rTMS sessions on oscillatory power to probe the capacity of rTMS to interfere with tinnitus-specific cortical plasticity. We measured 20 patients with bilateral chronic tinnitus and 20 healthy controls comparable for age, sex, handedness, and hearing level with a 63-channel electroencephalography (EEG) system. Educational level, intelligence, depressivity and hyperacusis were controlled for by analysis of covariance. Different rTMS protocols were tested: Left and right temporal and left and right prefrontal cortices were each stimulated with 200 pulses at 1 Hz and with an intensity of 60% stimulator output. Stimulation of central parietal cortex with 6-fold reduced intensity (inverted passive-cooled coil) served as sham condition. Before and after each rTMS protocol 5 min of resting state EEG were recorded. The order of rTMS protocols was randomized over two sessions with 1 week interval in between. Analyses on electrode level showed that people with and without tinnitus differed in their response to left temporal and right frontal stimulation. In tinnitus patients left temporal rTMS decreased frontal theta and delta and increased beta2 power, whereas right frontal rTMS decreased right temporal beta3 and gamma power. No changes or increases were observed in the control group. Only non-systematic changes in tinnitus loudness were induced by single sessions of rTMS. This is the first study to show tinnitus-related alterations of neuroplasticity that were specific to stimulation site and oscillatory frequency. The observed effects can be interpreted within the thalamocortical dysrhythmia model assuming that slow waves represent processes of deafferentiation and that high frequencies might be indicators for tinnitus loudness. Moreover our findings confirm the role of the left temporal and the right frontal areas as relevant hubs in tinnitus related neuronal network. Our results underscore the value of combined TMS-EEG measurements for investigating disease related changes in neuroplasticity. |
format | Online Article Text |
id | pubmed-4617176 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2015 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-46171762015-11-09 Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus Schecklmann, Martin Lehner, Astrid Gollmitzer, Judith Schmidt, Eldrid Schlee, Winfried Langguth, Berthold Front Cell Neurosci Neuroscience Chronic tinnitus is associated with neuroplastic changes in auditory and non-auditory cortical areas. About 10 years ago, repetitive transcranial magnetic stimulation (rTMS) of auditory and prefrontal cortex was introduced as potential treatment for tinnitus. The resulting changes in tinnitus loudness are interpreted in the context of rTMS induced activity changes (neuroplasticity). Here, we investigate the effect of single rTMS sessions on oscillatory power to probe the capacity of rTMS to interfere with tinnitus-specific cortical plasticity. We measured 20 patients with bilateral chronic tinnitus and 20 healthy controls comparable for age, sex, handedness, and hearing level with a 63-channel electroencephalography (EEG) system. Educational level, intelligence, depressivity and hyperacusis were controlled for by analysis of covariance. Different rTMS protocols were tested: Left and right temporal and left and right prefrontal cortices were each stimulated with 200 pulses at 1 Hz and with an intensity of 60% stimulator output. Stimulation of central parietal cortex with 6-fold reduced intensity (inverted passive-cooled coil) served as sham condition. Before and after each rTMS protocol 5 min of resting state EEG were recorded. The order of rTMS protocols was randomized over two sessions with 1 week interval in between. Analyses on electrode level showed that people with and without tinnitus differed in their response to left temporal and right frontal stimulation. In tinnitus patients left temporal rTMS decreased frontal theta and delta and increased beta2 power, whereas right frontal rTMS decreased right temporal beta3 and gamma power. No changes or increases were observed in the control group. Only non-systematic changes in tinnitus loudness were induced by single sessions of rTMS. This is the first study to show tinnitus-related alterations of neuroplasticity that were specific to stimulation site and oscillatory frequency. The observed effects can be interpreted within the thalamocortical dysrhythmia model assuming that slow waves represent processes of deafferentiation and that high frequencies might be indicators for tinnitus loudness. Moreover our findings confirm the role of the left temporal and the right frontal areas as relevant hubs in tinnitus related neuronal network. Our results underscore the value of combined TMS-EEG measurements for investigating disease related changes in neuroplasticity. Frontiers Media S.A. 2015-10-21 /pmc/articles/PMC4617176/ /pubmed/26557055 http://dx.doi.org/10.3389/fncel.2015.00421 Text en Copyright © 2015 Schecklmann, Lehner, Gollmitzer, Schmidt, Schlee and Langguth. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution and reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neuroscience Schecklmann, Martin Lehner, Astrid Gollmitzer, Judith Schmidt, Eldrid Schlee, Winfried Langguth, Berthold Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title | Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title_full | Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title_fullStr | Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title_full_unstemmed | Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title_short | Repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
title_sort | repetitive transcranial magnetic stimulation induces oscillatory power changes in chronic tinnitus |
topic | Neuroscience |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4617176/ https://www.ncbi.nlm.nih.gov/pubmed/26557055 http://dx.doi.org/10.3389/fncel.2015.00421 |
work_keys_str_mv | AT schecklmannmartin repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus AT lehnerastrid repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus AT gollmitzerjudith repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus AT schmidteldrid repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus AT schleewinfried repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus AT langguthberthold repetitivetranscranialmagneticstimulationinducesoscillatorypowerchangesinchronictinnitus |